A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 197

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 197
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 271
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 1075
Function: getPubMedXML

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3195
Function: GetPubMedArticleOutput_2016

File: /var/www/html/application/controllers/Detail.php
Line: 597
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 511
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 317
Function: require_once

Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis - a multicentre study. | LitMetric
Browse Categories

Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis - a multicentre study.

Harald Hegen , Klaus Berek , Paola Cavalla , Mikael Christiansen , Andreja Emeršič , Massimiliano Di Filippo , Lorenzo Gaetani , Michaela Hassler , Cyra Leurs , Dejan Milosavljevic , Vincent van Pesch , Thor Petersen , Stefan Presslauer , Igal Rosenstein , Uroš Rot , Christine Schnabl , Charlotte Teunissen , Domizia Vecchio , Marco Vercellino , Florian Deisenhammer

Front Immunol

Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.

Published: January 2024

Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Background: Kappa free light chains (κ-FLC) in the cerebrospinal fluid (CSF) are an emerging biomarker in multiple sclerosis (MS).

Objective: To investigate whether κ-FLC index has similar diagnostic value in patients with primary progressive multiple sclerosis (PPMS) compared to oligoclonal bands (OCB).

Methods: Patients with PPMS were recruited through 11 MS centres across 7 countries. κ-FLC were measured by immunonephelometry/-turbidimetry. OCB were determined by isoelectric focusing and immunofixation.

Results: A total of 174 patients (mean age of 52±11 years, 51% males) were included. κ-FLC index using a cut-off of 6.1 was positive in 161 (93%) and OCB in 153 (88%) patients.

Conclusion: κ-FLC index shows similar diagnostic sensitivity than OCB in PPMS.

Download full-text PDF

 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10758426PMC
http://dx.doi.org/10.3389/fimmu.2023.1327947DOI Listing

Publication Analysis

Top Keywords

multiple sclerosis
12
kappa free
8
free light
8
patients primary
8
primary progressive
8
progressive multiple
8
κ-flc diagnostic
8
κ-flc
5
diagnostic kappa
4
light chain
4

Similar Publications

Privacy Policy Site Map

© LitMetric 2025. All rights reserved.