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Purpose: To report a case of (neuro)sarcoidosis presenting solely with recurrent cranial nerve palsies in a 57-year-old Caucasian female.
Methods: Case report with clinical imaging.
Results: A 57-year-old female first presented with a right sixth nerve palsy, which resolved spontaneously after 6 months. Three years later she was diagnosed with a sixth nerve palsy in the fellow eye followed by a complete palsy of the left third cranial nerve four months after. Medical history consisted of migraine and hypercholesterolemia. Further neurological and ophthalmic work-up was unrevealing at first. After repeated magnetic resonance imaging, an enhancing lesion in the left cavernous sinus was seen, which was initially diagnosed as a meningioma. However, imaging of the chest revealed an image of sarcoidosis, and the lesion and ophthalmoplegia of the left eye disappeared with systemic corticosteroid treatment.
Discussion: Sarcoidosis is the ultimate imitator and the possibility of neurosarcoidosis must be taken into account when presented with unexplained ophthalmoplegia. Neurosarcoidosis has imaging properties very similar to other diseases such as a meningioma, and misdiagnosis occurs easily. Spontaneous recovery of ophthalmoplegia can rarely occur in neurosarcoidosis.
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http://dx.doi.org/10.3205/oc000229 | DOI Listing |
Otolaryngol Head Neck Surg
September 2025
Department of Otolaryngology-Head and Neck Surgery, University of California, San Diego, La Jolla, California, USA.
Objective: To summarize the outcomes of 1000 consecutive microsurgical resection of cerebellopontine angle tumors.
Study Design: Retrospective cohort study.
Setting: Single tertiary care institution.
PLoS One
September 2025
Faculty of Psychology, Mental Health Research and Treatment Center, Ruhr University Bochum, Bochum, Germany.
Background: Eating disorders such as Anorexia Nervosa (AN) and Bulimia Nervosa (BN) were previously found to partly entail alterations in stress physiology including salivary cortisol (sC), and salivary alpha amylase (sAA) at rest and basal vagal tone (HF-HRV), compared to individuals without mental disorders or with mixed mental disorders (anxiety and depressive disorders), but corresponding data remain scarce and are not entirely consistent.
Method: HF-HRV, sC and sAA at rest were assessed in a female sample of 58 individuals with AN and 54 individuals with BN before and after psychotherapy and contrasted against measurements from 59 female individuals suffering from mixed disorders and 101female healthy controls.
Results: Values for sC were elevated in AN compared to all other groups, those for HF-HRV were highest in both AN and BN and lowest in mixed mental disorders and no differences were found at rest for sAA.
Cureus
August 2025
Neurology, University of Texas Medical Branch, Galveston, USA.
Vertebrobasilar dolichoectasia (VBD) is a vascular anomaly marked by abnormal elongation and dilation of the vertebral and basilar arteries. Often, VBD remains undiagnosed or is discovered incidentally during evaluations of vascular events such as ischemia, hemorrhage, hydrocephalus, or cranial nerve palsies. While most patients are managed conservatively, treatment choices are highly individualized based on clinical presentation, vessel characteristics, and risk factors.
View Article and Find Full Text PDFAdv Med Educ Pract
August 2025
Medical Education Division, Weill Cornell Medicine - Qatar, Doha, Qatar.
Purpose: Neuroanatomy is a cornerstone of medical education, yet its complexity often leads to student apprehension, termed "neurophobia." This quantitative study evaluated the effectiveness of online Functional Neuroanatomy modules in enhancing second-year medical students' understanding of neuroanatomy at Weill Cornell Medicine-Qatar during the 2024-25 academic year.
Participants And Methods: Four functional neuroanatomy modules were developed: Brainstem Anatomy, Sensory Pathway, Motor Pathway, and Cranial Nerves.
J Neuroimaging
September 2025
Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Background And Purpose: To review the existing evidence on multiple timepoint assessments of optic nerve sheath diameter (ONSD) as an indicator of intraindividual variation of intracranial pressure (ICP).
Methods: A systematic search identified studies assessing intraindividual variation in ICP through multiple timepoint measurements of ONSD using ultrasonography. Meta-analysis of studies assessing intraindividual correlation coefficients between ONSD and ICP was performed using a random effects model, and we calculated the weighted correlation coefficient for the expected change in ICP associated with variations in ONSD.