Recurrent multiple eye muscle palsy as a first sign of sarcoidosis.

GMS Ophthalmol Cases

Department of Ophthalmology, Antwerp University Hospital, Edegem, Belgium.

Published: November 2023


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Purpose: To report a case of (neuro)sarcoidosis presenting solely with recurrent cranial nerve palsies in a 57-year-old Caucasian female.

Methods: Case report with clinical imaging.

Results: A 57-year-old female first presented with a right sixth nerve palsy, which resolved spontaneously after 6 months. Three years later she was diagnosed with a sixth nerve palsy in the fellow eye followed by a complete palsy of the left third cranial nerve four months after. Medical history consisted of migraine and hypercholesterolemia. Further neurological and ophthalmic work-up was unrevealing at first. After repeated magnetic resonance imaging, an enhancing lesion in the left cavernous sinus was seen, which was initially diagnosed as a meningioma. However, imaging of the chest revealed an image of sarcoidosis, and the lesion and ophthalmoplegia of the left eye disappeared with systemic corticosteroid treatment.

Discussion: Sarcoidosis is the ultimate imitator and the possibility of neurosarcoidosis must be taken into account when presented with unexplained ophthalmoplegia. Neurosarcoidosis has imaging properties very similar to other diseases such as a meningioma, and misdiagnosis occurs easily. Spontaneous recovery of ophthalmoplegia can rarely occur in neurosarcoidosis.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10726560PMC
http://dx.doi.org/10.3205/oc000229DOI Listing

Publication Analysis

Top Keywords

cranial nerve
8
sixth nerve
8
nerve palsy
8
recurrent multiple
4
multiple eye
4
eye muscle
4
palsy
4
muscle palsy
4
palsy sign
4
sign sarcoidosis
4

Similar Publications

Objective: To summarize the outcomes of 1000 consecutive microsurgical resection of cerebellopontine angle tumors.

Study Design: Retrospective cohort study.

Setting: Single tertiary care institution.

View Article and Find Full Text PDF

Background: Eating disorders such as Anorexia Nervosa (AN) and Bulimia Nervosa (BN) were previously found to partly entail alterations in stress physiology including salivary cortisol (sC), and salivary alpha amylase (sAA) at rest and basal vagal tone (HF-HRV), compared to individuals without mental disorders or with mixed mental disorders (anxiety and depressive disorders), but corresponding data remain scarce and are not entirely consistent.

Method: HF-HRV, sC and sAA at rest were assessed in a female sample of 58 individuals with AN and 54 individuals with BN before and after psychotherapy and contrasted against measurements from 59 female individuals suffering from mixed disorders and 101female healthy controls.

Results: Values for sC were elevated in AN compared to all other groups, those for HF-HRV were highest in both AN and BN and lowest in mixed mental disorders and no differences were found at rest for sAA.

View Article and Find Full Text PDF

Vertebrobasilar dolichoectasia (VBD) is a vascular anomaly marked by abnormal elongation and dilation of the vertebral and basilar arteries. Often, VBD remains undiagnosed or is discovered incidentally during evaluations of vascular events such as ischemia, hemorrhage, hydrocephalus, or cranial nerve palsies. While most patients are managed conservatively, treatment choices are highly individualized based on clinical presentation, vessel characteristics, and risk factors.

View Article and Find Full Text PDF

Enhancing Neuroanatomy Education for Medical Students Through the Development of Online Modules.

Adv Med Educ Pract

August 2025

Medical Education Division, Weill Cornell Medicine - Qatar, Doha, Qatar.

Purpose: Neuroanatomy is a cornerstone of medical education, yet its complexity often leads to student apprehension, termed "neurophobia." This quantitative study evaluated the effectiveness of online Functional Neuroanatomy modules in enhancing second-year medical students' understanding of neuroanatomy at Weill Cornell Medicine-Qatar during the 2024-25 academic year.

Participants And Methods: Four functional neuroanatomy modules were developed: Brainstem Anatomy, Sensory Pathway, Motor Pathway, and Cranial Nerves.

View Article and Find Full Text PDF

Background And Purpose: To review the existing evidence on multiple timepoint assessments of optic nerve sheath diameter (ONSD) as an indicator of intraindividual variation of intracranial pressure (ICP).

Methods: A systematic search identified studies assessing intraindividual variation in ICP through multiple timepoint measurements of ONSD using ultrasonography. Meta-analysis of studies assessing intraindividual correlation coefficients between ONSD and ICP was performed using a random effects model, and we calculated the weighted correlation coefficient for the expected change in ICP associated with variations in ONSD.

View Article and Find Full Text PDF