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Article Abstract
Background: Non-genetic factors like microbial dysbiosis may be contributing to the increasing incidence/progression of type 1 diabetes mellitus (T1DM).
Objectives: To analyse the gut microbiota profile in Indian children with T1DM and its effect on glycaemic control.
Methodology: Faecal samples of 29 children with T1DM were collected and faecal microbial DNA was extracted and subjected to 16S rRNA (ribosomal RNA) sequencing and further analysis.
Results: The dominant phyla in children with T1DM were Firmicutes and Bacteroidetes. Butyrate-producing bacteria and showed a significant negative correlation with the glycosylated haemoglobin (HbA1C) levels ( < 0.05). and were important negative predictors of glycaemic control ( < 0.05).
Conclusion: Our study suggests that Indian children with T1DM have a distinct gut microbiome taxonomic composition and that short-chain fatty acid-producing bacteria like and (butyrate-producing) may play an important role in the glycaemic control of subjects with T1DM.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10723603 | PMC |
| http://dx.doi.org/10.4103/ijem.ijem_22_22 | DOI Listing |
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