Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Modern health care faces several serious challenges, including an ageing population and its inherent burden of chronic diseases, rising costs and marginal quality metrics. By assessing and optimizing the health trajectory of each individual using a data-driven personalized approach that reflects their genetics, behaviour and environment, we can start to address these challenges. This assessment includes longitudinal phenome measures, such as the blood proteome and metabolome, gut microbiome composition and function, and lifestyle and behaviour through wearables and questionnaires. Here, we review ongoing large-scale genomics and longitudinal phenomics efforts and the powerful insights they provide into wellness. We describe our vision for the transformation of the current health care from disease-oriented to data-driven, wellness-oriented and personalized population health.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/s41576-023-00674-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Designing an AI companion to support informal caregivers in role transition: insights from a design science approach.
BMC Nurs
September 2025
Institute of Business Administration and Business Informatics, IT for the Caring Society, University of Hildesheim, Hildesheim, Germany.
Background: As populations age, informal caregivers play an increasingly vital role in long-term care, with 80% of care provided by family members in Europe. However, many individuals do not immediately recognize themselves as caregivers, especially in the early stages. This lack of awareness can increase physical and emotional stress and delay access to support services.
View Article and Find Full Text PDFASO Visual Abstract: Analysis of the 2024 Breast Surgical Oncology Fellowship Match: Survey of Applicants and Program Directors' Preferences Regarding In-Person Versus Virtual Interviews.
Ann Surg Oncol
September 2025
Department of Surgery, Division of Surgical Oncology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
Phenotypic age acceleration as a novel predictor of benign prostatic hyperplasia: a prospective cohort study.
Geroscience
September 2025
Department of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
This study aims to investigate the predictive value of combined phenotypic age and phenotypic age acceleration (PhenoAgeAccel) for benign prostatic hyperplasia (BPH) and develop a machine learning-based risk prediction model to inform precision prevention and clinical management strategies. The study analyzed data from 784 male participants in the US National Health and Nutrition Examination Survey (NHANES, 2001-2008). Phenotypic age was derived from chronological age and nine serum biomarkers.
View Article and Find Full Text PDFHLA polymorphisms in South Tunisian systemic sclerosis patients: a case-control study.
Clin Rheumatol
September 2025
Histocompatibility Department, Hedi Chaker UH, University of Sfax, Sfax, Tunisia.
Objective: Systemic sclerosis (SSc) is a complex autoimmune connective tissue disease. Genetic factors may play a pivotal role in determining susceptibility to these disorders. HLA associations with SSc, especially HLA class II, were investigated in different populations but not in Tunisia.
View Article and Find Full Text PDFDecompensation of degenerative lumbar stenosis: do patients need immediate surgery?
Eur Spine J
September 2025
Centre Hospitalier Universitaire de Tours, Tours, France.
Purpose: Degenerative lumbar spinal stenosis (DLSS) represents an increasing challenge due to the aging population. The natural course of untreated DLSS is largely unknown. For the acute DLSS decompensations, the main concern remains the opportunity and timing of surgery, i.
View Article and Find Full Text PDF