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Performance improvement methodologies do not currently include any structures that encourage analysis of how bias, inequity, or social determinants of health (SDOH) contribute to outcomes. The Montefiore Center for Performance Improvement developed a novel quality improvement (QI) toolkit that ingrains issues of diversity, equity, and inclusion (DEI) and SDOH into the Institute for Healthcare Improvement's tools. The toolkit prompts QI teams to evaluate DEI and SDOH at each step of the journey, including an updated charter and stratified baseline tool, a new fishbone diagram for the discovery phase with a tail to include DEI and SDOH, and additions in the Study and Act sessions of the Plan-Do-Study-Act worksheet to address these issues. After development and dissemination of this toolkit, the authors conducted a pre-post analysis of projects conducted by QI fellows in their institution. Prior to introducing the new toolkit, 22.9% of projects from 2016 to 2021 incorporated DEI/SDOH into any stage of the QI process. After implementing the amended tools, this increased to 88.9% in the 2022 fellowship. These results show that this simple approach can hardwire consideration of DEI and SDOH into improvement projects.
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http://dx.doi.org/10.1016/j.jcjq.2023.11.003 | DOI Listing |
medRxiv
July 2025
Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Objectives: Polygenic hazard score (PHS) models can be used to predict the age-associated risk for complex diseases, including Alzheimer's disease (AD). In this study, we present an improved PHS model for AD that incorporates a large number of genetic variants and demonstrates enhanced predictive accuracy for age of onset in European populations compared to alternative models.
Methods: We used the genotyped European Alzheimer & Dementia Biobank (EADB) sample (n=42,120) to develop and evaluate the performance of the PHS model.
Nat Genet
July 2025
U1167-RID-AGE facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Université Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.
A polygenic score (PGS) for Alzheimer's disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal fluid levels of AD biomarkers, independently of apolipoprotein E locus (APOE). This PGS was also associated with the AD risk in many other populations of diverse ancestries.
View Article and Find Full Text PDFChiropr Man Therap
May 2025
Department of Rehabilitation Sciences, McMaster University, 1280 Main St. W, Hamilton, ON, Canada.
Background: Health inequities disproportionately impact equity-deserving groups, which include individuals marginalized due to race, ethnicity, Indigenous identity, sex and gender, socioeconomic status, and other social determinants of health. This qualitative study aimed to explore Canadian chiropractors' experiences and perceptions in delivering care to equity-deserving groups and identify individual and institutional factors that may influence care delivery.
Methods: We utilized interpretive description for data development, sampling, collection, and analysis.
J Educ Teach Emerg Med
April 2025
Cooper Medical School of Rowan University, Cooper University Health Care, Department of Emergency Medicine, Camden, New Jersey.
Audience: Medical students on required fourth-year emergency medicine clerkship.
Introduction: Social determinants of health are the nonmedical factors that influence health outcomes.1 As part of the AMA Accelerating Change in Medical Education Consortium's third pillar of medical education, health systems science, social determinants of health are recognized as critical components to medical student education.
BMC Med Ethics
April 2025
Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, 1645 W Jackson Blvd Ste 302, Chicago Illinois, Chicago, IL, 60612, United States of America.
Introduction: Current research documents both the historical impact of racism in healthcare as well as studies piloting antiracist interventions as part of medical training to ameliorate its stigma, bias, and consequences in medicine. The purpose of this study was to qualitatively analyze the impact of a one session lecture surrounding racial issues in psychiatry on third-year medical students' thoughts and reflections surrounding the content.
Methodology: Remote methodologies were used to engage medical students in a lecture created by a major University's Substance Use Disorder Center of Excellence to address the legacy of racial issues in psychiatry as well as present interventions.