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Inaccurate penicillin allergy labels may be delabelled following evaluation. The intervention in this study was an email-based notification system regarding the appropriateness for penicillin allergy evaluation, with a view to delabelling, as identified by a deep learning artificial intelligence algorithm. Of the intervention group (n = 59), three (5.1%) individuals had their penicillin allergies delabelled, which was significantly more than the control group (0%, P = 0.002). Further research to optimise such approaches is required.
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http://dx.doi.org/10.1111/imj.16266 | DOI Listing |
Klin Mikrobiol Infekc Lek
June 2025
Department of Infectious Diseases and Travel Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic, e-mail:
Skin and soft tissue infections (SSTIs) represent a diverse spectrum of conditions, including erysipelas, cellulitis, cutaneous abscesses, necrotizing fasciitis, and myonecrosis. Erysipelas and cellulitis are the most common community-acquired SSTIs. Erysipelas is typically caused by pyogenic streptococci, while cellulitis often has a staphylococcal etiology.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Infectious Diseases, at the Peter Doherty Institute for Infection and Immunology, Melbourne Medical School, University of Melbourne, Melbourne, Victoria, Australia.
Background: Penicillin allergies are reported in 1 in 10 hospitalised patients globally and are associated with inferior patient and health service outcomes. However, more than 95% of low-risk penicillin allergies can be removed by direct oral challenge (DOC).
Objective: The International Network of Antibiotic Allergy Nations (iNAAN) aims to evaluate the utility of an audit and feedback (A&F) and education implementation strategy to increase the adoption of penicillin DOC in patients with a low-risk penicillin allergy, while concurrently assessing the impact of penicillin DOC on antibiotic prescribing and health service outcomes.
Cureus
August 2025
Internal Medicine, Unidade Local de Saúde do Alto Ave, Guimarães, PRT.
Toxic epidermal necrolysis (TEN) is a rare, life-threatening mucocutaneous condition, most commonly triggered by drugs, with particularly high mortality in elderly populations. The medications most frequently associated with TEN include antibiotics such as sulfamethoxazole-trimethoprim (sulfonamides), penicillins, cephalosporins, and quinolones (e.g.
View Article and Find Full Text PDFAllergy
September 2025
Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.
Background: A subset of patients experience immune-mediated hypersensitivity reactions towards β-lactam antibiotics, with drug-specific T cells implicated as one of the causative factors. The principal mechanism is thought to involve chemical haptenation of self-peptides, resulting in novel peptide drug-adducts that may trigger T cell recognition. Understanding the interactions between the β-lactam drug, the T cell receptor (TCR) and the peptide/human leukocyte antigen (pHLA) complex is critical to gain further mechanistic insights into these hypersensitivity reactions.
View Article and Find Full Text PDFN Engl J Med
September 2025
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD.
Background: Controversy persists regarding the appropriate duration of therapy with benzathine penicillin G in persons with early (i.e., primary, secondary, or early latent) syphilis ( infection).
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