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http://dx.doi.org/10.1182/bloodadvances.2023011916 | DOI Listing |
United European Gastroenterol J
September 2025
Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Background: Remimazolam is a short-acting benzodiazepine with less cardiorespiratory depression compared with propofol. The Oxygen Reserve Index (ORi) reflects oxygenation status in the mild hyperoxic range and can detect subtle respiratory depression induced by sedatives.
Objective: We compared remimazolam and propofol in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) and assessed the ORi to evaluate the impact of these sedatives on oxygen reserve.
Background Over 300 mutations in have been identified as causes of early-onset Alzheimer's disease (EOAD). While these include missense mutations and a few insertions, deletions, or duplications, none result in open reading frame shifts, and all alter γ-secretase function to increase the long/short Aβ ratio. Methods We identified a novel heterozygous nonsense variant, c.
View Article and Find Full Text PDFRSC Adv
August 2025
Key Laboratory of Engineering Plastics, Beijing National Laboratory for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences Beijing 100190 China
Iminopyridine nickel catalysts are typically prone to facile chain transfer reactions, resulting in low molecular weight polyethylenes. In this study, a spatial proximity strategy was employed in 5-dibenzosuberyl-modified iminopyridine nickel catalysts to enhance ethylene polymerization. Using a template reaction between acetylpyridine and 5-dibenzosuberyl-functionalized aniline, a series of 2-(1-(2,6-bis(5-dibenzosuberyl)-4-(alkyl)phenylimino)ethyl)pyridine ligands were synthesized and subsequently reacted with (1,2-dimethoxyethane)NiBr to afford the corresponding nickel complexes.
View Article and Find Full Text PDFJ Visc Surg
September 2025
Department of Visceral and Digestive Surgery, Timone Hospital, Marseille, France. Electronic address:
Ureteral complications occur rarely during colorectal surgery (0.3 to 1.5%), are mainly diagnosed postoperatively (50-70%), and result in both short- and long-term morbidity.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, U.K.
Tuberculosis (TB), caused by , remains a global health emergency, particularly in low- and middle-income countries. Despite effective pharmacotherapy, prolonged treatment, poor adherence, and drug resistance continue to hinder eradication. Isoniazid (ISZ), a first-line antitubercular drug, is effective but limited by high aqueous solubility and short half-life, necessitating daily administration and causing plasma fluctuations.
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