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http://dx.doi.org/10.1183/23120541.00138-2023 | DOI Listing |
In Vivo
August 2025
Department of Respiratory Medicine, University Hospital of Heraklion, Heraklion, Greece;
Background/aim: Chronic airway diseases, including chronic obstructive pulmonary disease (COPD), asthma, and asthma COPD overlap (ACO), are characterized by complex inflammatory processes in which Activin A-a key member of the TGF-β superfamily-is implicated. Although its role in the stable state of these diseases has been extensively studied, data regarding its involvement during exacerbations remain limited. Our objective was to investigate the dynamics of Activin A in sputum and serum during acute exacerbations and subsequent convalescence in patients with chronic airway diseases.
View Article and Find Full Text PDFGenes (Basel)
July 2025
Pediatric Laboratory, Department of Public Health and Pediatric Sciences, University of Turin, Regina Margherita Children's Hospital, 10126 Turin, Italy.
Background: Respiratory syncytial virus (RSV) bronchiolitis is a leading cause of lower respiratory tract infections in children under two years of age. NF-κB is a key transcription factor in antiviral and inflammatory responses. This study investigates the expression of NF-κB mRNA in both blood and buccal swab samples of pediatric patients hospitalized for RSV bronchiolitis, comparing levels at admission and discharge.
View Article and Find Full Text PDFInt J Mol Sci
August 2025
Department of Dermatology, Zealand University Hospital, 4600 Roskilde, Denmark.
T lymphocytes in human skin play essential roles in immune surveillance and tissue homeostasis, with distinct populations residing in the epidermal and dermal compartments. To characterize the molecular basis of their compartmentalized functional specialization, we performed proteomic analysis of total T cell populations isolated from healthy human skin, combining flow cytometry and liquid chromatography-tandem mass spectrometry. We quantified 5985 proteins across epidermal and dermal T cell populations, identifying 2177 significantly differentially expressed proteins (FDR < 0.
View Article and Find Full Text PDFFront Immunol
August 2025
Division of Reproductive Sciences, Department of Obstetrics and Gynecology University of Wisconsin, Madison, WI, United States.
Background: Persistent low-grade inflammation has been hypothesized as a possible key contributor to polycystic ovary syndrome pathophysiology through associative studies. Since immune cells within the ovarian follicle-the central site of PCOS dysfunction-play pivotal roles in immune defense and regulation of ovulation, establishing a definitive cellular map of normal and PCOS-affected follicular immune composition is essential.
Method: This is a prospective cohort study of women with PCOS (Rotterdam criteria) and controls undergoing fertilization (IVF).
Brain Behav Immun
August 2025
Institute for Cell Engineering, Division of Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA. Electronic address:
Herpes simplex encephalitis (HSE) patients may develop secondary anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis (NMDARE), associated with worsened long-term neurological outcome. Immunosuppressive treatment can limit NMDAR autoantibody-mediated pathology, but early predictive biomarkers for the risk of NMDARE are lacking. In a multicenter study, we performed unbiased antibody reactome profiling using Phage ImmunoPrecipitation Sequencing (PhIP-Seq).
View Article and Find Full Text PDF