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Allostatic load refers to a vulnerable state of the nervous system caused by chronic or repeated exposure to challenges of daily life (e.g., psychological stressors) and considered to indicate risk of a transition to pathological state. In this paper, we first introduce a traditional method of assessing allostatic load that utilizes multiple biomarkers. Next, we demonstrate the potential of the Internet of Things (IoT) data sampling method to detect and control the vulnerable state in daily life.
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http://dx.doi.org/10.11477/mf.1416202507 | DOI Listing |
J Alzheimers Dis
September 2025
Amsterdam Public Health, Aging & Later life and Personalized Medicine, Amsterdam, the Netherlands.
BackgroundAllostatic load (AL), an umbrella term for the physiological response to chronic stress, is different in women and men. AL has also been associated with all-cause dementia.ObjectiveThe current study investigates if AL clusters differently in men and women, and if these sex-based clusters are associated with all-cause dementia.
View Article and Find Full Text PDFCompr Physiol
October 2025
School of Pharmacy and Medical Sciences, Griffith University, Southport, Queensland, Australia.
Mechanisms underlying cardiovascular, affective, and metabolic (CAM) multimorbidity are incompletely defined. We assessed how two risk factors-chronic stress (CS) and a Western diet (WD)-interact to influence cardiovascular function, resilience, adaptability, and allostatic load (AL); explore pathway involvement; and examine relationships with behavioral, metabolic, and systemic AL. Male C57Bl/6 mice (8 weeks old, n = 64) consumed a control (CD) or WD (12%-65%-23% or 32%-57%-11% calories from fat-carbohydrate-protein) for 17 weeks, with half subjected to 2 h daily restraint stress over the final 2 weeks (CD + CS and WD + CS).
View Article and Find Full Text PDFJ Biomed Inform
September 2025
Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, 27157, NC, USA.
Objective: The allostatic load index (ALI) is a 10-component composite measure of whole-person health, which reflects the multiple interrelated physiological regulatory systems that underlie healthy functioning. Data from electronic health records (EHR) present a huge opportunity to operationalize the ALI in learning health systems; however, these data are prone to missingness and errors. Validation (e.
View Article and Find Full Text PDFObstet Gynecol
September 2025
Department of Health Promotion and Development, the Department of Human Genetics, the Department of Epidemiology, and the Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, and Magee-Womens Research Institute, Pittsburgh, and the Department of Obstetrics and G
Objective: To evaluate whether chronic stress exposure, measured by allostatic load (a biological measure of chronic stress embodiment, including stressors exacerbated by structural inequities [eg, structural racism]) and patient-reported perceived stress in the first trimester of pregnancy, mediates the association between self-identified race and ethnicity and hypertensive disorders of pregnancy (HDP).
Methods: This was a secondary analysis of data from nuMoM2b (Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be), a large prospective cohort study. We evaluated self-identified race and ethnicity as an independent variable (non-Hispanic Black, Hispanic, Asian, non-Hispanic White), and our outcome of interest was HDP (ie, gestational hypertension, preeclampsia or eclampsia).
Acta Psychiatr Scand
September 2025
Department of Psychology "Renzo Canestrari", University of Bologna, Bologna, Italy.
Clinical judgment is currently perceived as an intuitive art that is going to be replaced by growing technology and artificial intelligence. Even though patients look for good clinical judgment when they seek medical attention and clinicians rely on it, the topic is seldom mentioned and discussed in the literature. In their everyday practice, psychiatrists use observation, description, and classification; test explanatory hypotheses; and formulate clinical decisions based on clinical judgment.
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