Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Rationale: Children's bones are in the process of growing in both length and width. Therefore, evaluating whether fractures affect the growth plate or not is very crucial. However, even in cases of lower limb fractures where the growth plate remains unaffected, overgrowth or shortening of the affected limb are encountered.
Patient Concerns: An 11-year-old boy was admitted to the emergency department after a passenger car accident.
Diagnoses: A comminuted fracture of the right femoral shaft was diagnosed by X-ray image.
Interventions: Closed reduction and internal fixation were performed using intramedullary titanium elastic nails. Six months after the operation, bone union was achieved and the nails were removed.
Outcomes: Nine months after nail removal, the right leg was unexpectedly noticed 5 mm shorter than the left one. On the initial and follow-up bone single-photon emission computed tomography/computed tomography images with a 9-month interval, radioactivity of growth plate in the right proximal femur was much lower than that of the left femur, suggesting a further increasing of leg-length discrepancy (LLD) in the future. As we expected, LLD had progressively increased up to 20 mm. Epiphysiodesis was finally decided for the left distal femur. Twenty-two months after the length equalization operation, LLD decreased to 5 mm.
Lessons: This case emphasizes that quantitative analysis of growth plate activity using bone single-photon emission computed tomography/computed tomography could predict LLD and help us decide when and which limb should be operated on for pediatric patients with lower limb fractures.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627618 | PMC |
| http://dx.doi.org/10.1097/MD.0000000000035860 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of Serum/Xeno-Free Medium and Cytokine Supplementation on CAR-T Cell Therapy Manufacturing in Stirred Tank Bioreactors.
Biotechnol J
September 2025
Department of Biochemical Engineering, University College London, London, UK.
Chimeric antigen receptor T-cell (CAR-T) therapies have demonstrated clinical efficacy in treating haematological malignancies, resulting in multiple regulatory approvals. However, there is a need for robust manufacturing platforms and the use of GMP-aligned reagents to meet the clinical and commercial demands. This study investigates the impact of serum/xeno-free medium (SXFM) and cytokine supplementation on CAR-T cell production in static and agitated culture systems, using 24-well plate G-Rex vessels and 500 mL stirred tank bioreactors (STRs), respectively.
View Article and Find Full Text PDFA case report and literature analysis of a rare nonossifying fibroma of the mandible.
Medicine (Baltimore)
September 2025
Department of Medical Imaging, Central Laboratory of Jinan Stomatological Hospital, Jinan Key Laboratory of Oral Tissue Regeneration, Jinan, Shandong Province, China.
Abstract Rationale: Nonossifying fibroma (NOF) is one of the benign bone tumors in adolescents, and it rarely occurs in the jawbone. According to the site of onset, it is divided into the cortical type and the medullary type. Currently, there is no case report of medullary NOF in the mandible of the elderly.
View Article and Find Full Text PDFPost-traumatic Distal Femoral Salter-Harris Type II Fracture Unmasking an Incidental Osteochondroma as a Possible Stress Riser: A Case Report With Surgical Management.
Cureus
August 2025
Central Institute of Orthopaedics, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, IND.
Osteochondromas are the most common benign bone tumors and are frequently discovered incidentally in the metaphyseal regions of long bones during growth. While typically asymptomatic, they may occasionally lead to complications such as neurovascular impingement, mechanical irritation, or pathological fractures. Salter-Harris type II fractures represent the most frequent physeal injuries in pediatric populations, particularly in rapidly growing regions like the distal femur.
View Article and Find Full Text PDFCase Report: The widening genetic and phenotypic spectrum of ultra-rare PDE4D-related acroscyphodysplasia.
Front Med (Lausanne)
August 2025
Research Centre for Medical Genetics, Moscow, Russia.
Acroscyphodysplasia (ASD) is an ultra-rare skeletal dysplasia characterized by severe brachydactyly, metaphyseal scaphoid knee deformities, growth retardation, and intellectual disability. To date, only seven cases of ASD have been reported, all associated with missense variants in the gene. We report a 7-year-old girl with ASD features, including midface hypoplasia, severe growth retardation (-4.
View Article and Find Full Text PDFHuman diseases caused by homozygous PTH1R mutations.
Front Endocrinol (Lausanne)
September 2025
Endocrine Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, United States.
The parathyroid hormone receptor type 1 (PTH1R) is a G protein-coupled receptor that mediates the actions of parathyroid hormone (PTH) in the regulation of blood calcium levels, as well as PTH-related protein (PTHrP) in the regulation of skeletal development. Severe loss-of-function homozygous mutations in PTH1R are incompatible with life as in Blomstrand's lethal chondrodysplasia, characterized by accelerated growth plate ossification. More recently, homozygous mutations located in the transmembrane helices, extracellular domains and C-tail of the PTH1R were identified in patients with milder conditions characterized by variable degrees of skeletal and mineral abnormalities.
View Article and Find Full Text PDF