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The PCOS Phenotypes in Unselected Populations (P-PUP) study: participant clinical features and data harmonization on analysis of individual participant data.
BMC Med
July 2025
Monash Centre for Health Research and Implementation, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, 3168, Australia.
Background: Polycystic ovary syndrome (PCOS) is a multifaceted condition with diagnostic challenges and clinical heterogeneity across populations. Research priorities include enhanced accuracy in defining cut-offs for diagnostic features. Here, we aim to describe participant clinical features and data harmonization in the international PCOS Phenotype in Unselected Populations (P-PUP) study.
View Article and Find Full Text PDFSleep disorders and psychological comorbidities in women with polycystic ovary syndrome - a cross-sectional study.
Arch Gynecol Obstet
August 2025
Department of Obstetrics and Gynecology, University Clinic Inselspital Bern, Bern, Switzerland.
Purpose: Polycystic ovary syndrome (PCOS) is a metabolic and hormonal disorder that affects physical and emotional well-being. The aim of this cross-sectional study was to assess associated factors like sleep disturbance, obstructive sleep apnea (OSA), anxiety and depression in a German-speaking population with PCOS.
Methods: We designed an anonymous online survey with items from validated questionnaires, including the Hospital Anxiety and Depression Scale (HADS), the Generalized Anxiety Disorder (GAD-7), the Pittsburgh Sleep Quality Index (PSQI) and the STOP-Bang questionnaire to screen for OSA.
Ripasudil does not induce phospholipid accumulation in human corneal epithelial cells.
Exp Eye Res
June 2025
Department of Ophthalmology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Rho-associated coiled-coil-containing protein kinase (Rho kinase; ROCK) inhibitors represent a novel class of glaucoma medications that lower intraocular pressure by enhancing aqueous humor outflow through the conventional outflow pathway. Netarsudil, a ROCK inhibitor, is known to induce cornea verticillata as an adverse effect in clinical settings. Unlike systemic amiodarone and antimalarials, topical agents do not typically induce the development of this corneal condition.
View Article and Find Full Text PDFAdult granulosa cell tumor with rare pulmonary presentation.
Respir Med Case Rep
February 2025
Genesis Cancer and Blood Institute, Hot Springs, AR, USA.
Adult granulosa cell tumor (GCT) is an uncommon sex cord-stromal neoplasm of the ovary. It typically demonstrates locoregional spread, and disease outside of the pelvis as metastasis is uncommon. Only a rare case of primary thoracic adult GCT has been documented, and here we describe another occurrence with unusual pulmonary presentation, thereby expanding the anatomic distribution across which adult GCT could potentially arise.
View Article and Find Full Text PDFThe PCOS Phenotype in Unselected Populations study: ethnic variation in population-based normative cut-offs for defining hirsutism.
Eur J Endocrinol
March 2025
Departments of Obstetrics and Gynecology, and Medicine, University of Alabama at Birmingham, Birmingham, AL 35243, United States.
Objective: Hirsutism, a diagnostic feature of polycystic ovary syndrome (PCOS), is often defined using arbitrary percentile cutoffs, rather than normative cutoffs from population-based data. We aimed to define normative cutoffs for hirsutism in diverse populations.
Design: Unselected population-based cluster analysis of individual participant data (IPD).