Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: Patients with obsessive-compulsive disorder (OCD) and poor insight show higher symptom severity, lower quality of life (QoL), and a reduced treatment response compared to patients with good insight. Little is known about changes in insight. This study explored the course of insight and its association with OCD severity and QoL among 253 patients with OCD participating in the prospective naturalistic Netherlands Obsessive Compulsive Disorder Association (NOCDA) Study.
Results: In 70% of the participants with available insight data, the level of insight changed during the four-year course. Insight was most variable in participants with poor insight. Improvement of insight scores was statistically significantly associated with improvement of Y-BOCS scores ( = 0.19), but not with changes in QoL scores. Change in insight in the first 2 years was not statistically significantly predictive of OCD severity or QoL at four-year follow-up.
Conclusion: These findings suggest that patients' levels of insight may change during the natural four-year course of OCD and that improvement in the level of insight have a positive association with improvement in OCD severity.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613061 | PMC |
| http://dx.doi.org/10.3389/fpsyt.2023.1231293 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Beta Rhythm Predicts Treatment Response to Deep Transcranial Magnetic Stimulation in Patients with Treatment-Resistant Obsessive-Compulsive Disorder.
Clin EEG Neurosci
September 2025
Department of Psychiatry, NPI Brain Hospital, Uskudar University, Istanbul, Turkey.
IntroductionObsessive-compulsive disorder (OCD) affects 1.1-1.8% of the population, and adult females are more likely to suffer from it.
View Article and Find Full Text PDFBackground: Obsessive-compulsive disorder (OCD) can cause physical complications, and psychiatric treatment sometimes improves these complications. However, it remains unclear whether managing a physical complication can contribute to the improvement of psychiatric symptoms or may alter the trajectory of psychiatric treatment.
Case Presentation: We report on a woman in her 50s with severe, long-standing, treatment-resistant OCD centered on contamination fears and compulsive defecation rituals.
Therapeutic effects of striatal dopaminergic modulation on idiopathic dystonia and OCD in humans: insights from the striosome hypothesis.
Front Hum Neurosci
August 2025
Center for Drug Discovery and Development Sciences, Research Organization of Science and Technology, Ritsumeikan University, Kyoto, Japan.
Emerging evidence suggests that striatal striosomes play a key role in the dopaminergic regulation of motor and mental action selection processes, with impairments leading to repetitive stereotyped movements (dystonias), thoughts (obsessions), and behaviors (compulsions). To explore this hypothesis therapeutically, we investigated how idiopathic dystonia and obsessive-compulsive disorder (OCD) respond to a novel dopaminergic treatment using low-dose L-DOPA combined with chlorpromazine (CPZ), which can primarily enhance striosomal D dopamine receptor (DR) signaling in humans. The therapeutic effects of L-DOPA/CPZ were assessed over 1 year in 26 idiopathic dystonia patients (mean age, 55.
View Article and Find Full Text PDFExecutive control in Obsessive-Compulsive Disorder: A worldwide mega-analysis of task-based functional neuroimaging data of the ENIGMA-OCD consortium.
bioRxiv
August 2025
Amsterdam UMC, Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Objective: Obsessive-compulsive disorder (OCD) is associated with impaired executive function and altered activity in associated neural circuits, contributing to reduced goal-directed behavior. To investigate neural activation during executive control, we conducted a mega-analysis in the ENIGMA-OCD consortium pooling individual participant data from 475 individuals with OCD and 345 healthy controls across 15 fMRI tasks collected worldwide.
Methods: Individual participant data was uniformly processed using HALFpipe to construct voxelwise statistical images of executive control and task load contrasts.
Is TBS an effective add-on therapy in treatment-resistant OCD? - A randomized controlled trial.
J Affect Disord
August 2025
Department of Clinical Neuroscience, Wroclaw University of Science and Technology, Wroclaw, Poland. Electronic address:
The exploration of Theta Burst Stimulation (TBS) in Obsessive-compulsive disorder (OCD) treatment is still in its nascent stages, and these initial findings underscore the need for further research to optimize stimulation parameters and identify patient subgroups that may benefit the most from this intervention. The current paper aims to contribute to this growing body of literature by presenting original randomized controlled trial research on the efficacy of Intermittent and Continuous TBS as add-on interventions in treatment-resistant OCD. The study was conducted between December 2019 and December 2022 in a randomized, double-blind, sham-controlled design.
View Article and Find Full Text PDF