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Complex networks capture the structure, dynamics, and relationships among entities in real-world networked systems, encompassing domains like communications, society, chemistry, biology, ecology, politics, etc. Analysis of complex networks lends insight into the critical nodes, key pathways, and potential points of failure that may impact the connectivity and operational integrity of the underlying system. In this work, we investigate the topological properties or indicators, such as shortest path length, modularity, efficiency, graph density, diameter, assortativity, and clustering coefficient, that determine the vulnerability to (or robustness against) diverse attack scenarios. Specifically, we examine how node- and link-based network growth or depletion based on specific attack criteria affect their robustness gauged in terms of the largest connected component (LCC) size and diameter. We employ partial least squares discriminant analysis to quantify the individual contribution of the indicators on LCC preservation while accounting for the collinearity stemming from the possible correlation between indicators. Our analysis of 14 complex network datasets and 5 attack models invariably reveals high modularity and disassortativity to be prime indicators of vulnerability, corroborating prior works that report disassortative modular networks to be particularly susceptible to targeted attacks. We conclude with a discussion as well as an illustrative example of the application of this work in fending off strategic attacks on critical infrastructures through models that adaptively and distributively achieve network robustness.
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http://dx.doi.org/10.1038/s41598-023-45218-9 | DOI Listing |
Stroke
September 2025
Department of Neurology, Yale School of Medicine, New Haven, CT (L.H.S.).
Preclinical stroke research faces a critical translational gap, with animal studies failing to reliably predict clinical efficacy. To address this, the field is moving toward rigorous, multicenter preclinical randomized controlled trials (mpRCTs) that mimic phase 3 clinical trials in several key components. This collective statement, derived from experts involved in mpRCTs, outlines considerations for designing and executing such trials.
View Article and Find Full Text PDFRev Med Liege
September 2025
Service de psychologie clinique et d'action sociale, ULiège, Belgique.
Patients with complex care needs present numerous challenges: the care they receive is often associated with more hospital admissions. The care provided to this group could benefit from being more goal-oriented and better integrated. However, strengthening a net-work of care for these patients starting from hospitalization remains a challenge.
View Article and Find Full Text PDFBJPsych Bull
September 2025
Department of Psychiatry, Kyoto University, Kyoto, Japan.
Heated online communication reveals global challenges in the digital age, often fuelled by collective outrage. This article investigates how Buddhist network perspectives, paralleling digital reality, can inform mental health. Avatamsaka philosophy provides practical ways to navigate web complexities, suggesting that individual actions ripple across society.
View Article and Find Full Text PDFPeriodontol 2000
September 2025
Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Oral cancer is a major global health burden, ranking sixth in prevalence, with oral squamous cell carcinoma (OSCC) being the most common type. Importantly, OSCC is often diagnosed at late stages, underscoring the need for innovative methods for early detection. The oral microbiome, an active microbial community within the oral cavity, holds promise as a biomarker for the prediction and progression of cancer.
View Article and Find Full Text PDFHum Brain Mapp
September 2025
Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.
Postoperative aphasia (POA) is a common complication in patients undergoing surgery for language-eloquent lesions. This study aimed to enhance the prediction of POA by leveraging preoperative navigated transcranial magnetic stimulation (nTMS) language mapping and diffusion tensor imaging (DTI)-based tractography, incorporating deep learning (DL) algorithms. One hundred patients with left-hemispheric lesions were retrospectively enrolled (43 developed postoperative aphasia, as the POA group; 57 did not, as the non-aphasia (NA) group).
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