fastlin: an ultra-fast program for Mycobacterium tuberculosis complex lineage typing.

Bioinformatics

MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London W12 0BZ, United Kingdom.

Published: November 2023


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Summary: Fastlin is a bioinformatics tool designed for rapid Mycobacterium tuberculosis complex (MTBC) lineage typing. It utilizes an ultra-fast alignment-free approach to detect previously identified barcode single nucleotide polymorphisms associated with specific MTBC lineages. In a comprehensive benchmarking against existing tools, fastlin demonstrated high accuracy and significantly faster running times.

Availability And Implementation: fastlin is freely available at https://github.com/rderelle/fastlin and can easily be installed using Conda.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627351PMC
http://dx.doi.org/10.1093/bioinformatics/btad648DOI Listing

Publication Analysis

Top Keywords

mycobacterium tuberculosis
8
tuberculosis complex
8
lineage typing
8
fastlin
4
fastlin ultra-fast
4
ultra-fast program
4
program mycobacterium
4
complex lineage
4
typing summary
4
summary fastlin
4

Similar Publications

This research work details the use of a molecular hybridization technique to create a library of four series of hydrazineyl-linked imidazo[1,2-]pyrimidine-thiazole derivatives. The structure of one of the final products, K2, was validated using single-crystal X-ray diffraction. Twenty-six novel hybrid molecules (K1-K26) were synthesized and tested for activity against the H37Rv strain.

View Article and Find Full Text PDF

Case Report: Sarcoidosis or tuberculosis? A continuous challenge.

Front Med (Lausanne)

August 2025

Department of Pulmonology, Institute of Pneumology, Bucharest, Romania.

Sarcoidosis is a multisystem granulomatous disorder of unknown etiology, characterized by the formation of non-caseating granulomas in affected tissues and organs. In over half of the cases, the disease undergoes spontaneous remission. In contrast, tuberculosis (TB) is an infectious disease caused by , which, if left untreated, can be fatal.

View Article and Find Full Text PDF

Tuberculosis (TB) is a multisystem infectious disease with both pulmonary and extrapulmonary manifestations. TB can also induce a hypercoagulable state, setting off a cascade of changes in the body, including systemic inflammation, endothelial dysfunction, and abnormalities in the coagulation and fibrinolytic pathways. Collectively, these factors significantly increase the risk of venous thromboembolism, such as deep vein thrombosis and pulmonary embolism.

View Article and Find Full Text PDF

A 27-year-old man from Ethiopia had undergone an extraction of a molar in Libya ten months earlier, after which a submental swelling developed. For that reason, an oral and maxillofacial surgery department was consulted. Clinical examination showed a tender, firm-to-the-touch, non-mobile swelling with central ulceration.

View Article and Find Full Text PDF

Molecular hybridization of isoniazid with hydrophobic aromatic moieties represents a promising strategy for the development of novel anti-tubercular therapeutics. In this study, a series of hybrid molecules (5a-i) was synthesized by linking isoniazid with aromatic sulfonate esters via a hydrazone bridge. Molecular docking studies revealed that these compounds interact effectively with the catalytic triad of the InhA enzyme (Y158, F149, and K165), suggesting their potential as InhA inhibitors.

View Article and Find Full Text PDF