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Event segmentation theory posits that people segment continuous experience into discrete events and that event boundaries occur when there are large transient increases in prediction error. Here, we set out to test this theory in the context of story listening, by using a deep learning language model (GPT-2) to compute the predicted probability distribution of the next word, at each point in the story. For three stories, we used the probability distributions generated by GPT-2 to compute the time series of prediction error. We also asked participants to listen to these stories while marking event boundaries. We used regression models to relate the GPT-2 measures to the human segmentation data. We found that event boundaries are associated with transient increases in Bayesian surprise but not with a simpler measure of prediction error (surprisal) that tracks, for each word in the story, how strongly that word was predicted at the previous time point. These results support the hypothesis that prediction error serves as a control mechanism governing event segmentation and point to important differences between operational definitions of prediction error.
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http://dx.doi.org/10.1111/cogs.13343 | DOI Listing |
Nat Comput Sci
September 2025
Department of Chemical Engineering, Tsinghua University, Beijing, China.
With approximately 90% of industrial reactions occurring on surfaces, the role of heterogeneous catalysts is paramount. Currently, accurate surface exposure prediction is vital for heterogeneous catalyst design, but it is hindered by the high costs of experimental and computational methods. Here we introduce a foundation force-field-based model for predicting surface exposure and synthesizability (SurFF) across intermetallic crystals, which are essential materials for heterogeneous catalysts.
View Article and Find Full Text PDFMed Eng Phys
October 2025
Ansys Inc., Houston, TX 77094, USA.
Introduction: Benchtop and animal models have traditionally been used to study the propagation of Onyx Liquid Embolic Systems (Onyx) used in the treatment of brain arteriovenous malformations (AVM). However, such models are costly, do not provide sufficient detail to elucidate how variations in Onyx viscosity alter flow dynamics, and rely on some trial-and-error, resulting in elongated timelines for product development.
Objectives: The goal of this study was to leverage Computational Fluid Dynamics (CFD) simulations to predict the behavior of different Onyx formulations.
Eur J Pharm Biopharm
September 2025
Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China. Electronic address:
Prodrugs with enzymatic activation requirements, such as the weakly basic biopharmaceutical classification system (BCS) class IV compound abiraterone acetate (ABA), face considerable bioequivalence (BE) risks owing to their pH-dependent solubility, food effects, and variable intestinal hydrolysis. This study established clinically relevant dissolution specifications for ABA using biorelevant dissolution and physiologically based biopharmaceutics modelling (PBBM). Two dissolution methods, two-stage (gastrointestinal transfer simulation) and single-phase (biorelevant media), were evaluated under fasted and fed conditions.
View Article and Find Full Text PDFFood Chem
September 2025
Group of Chemical Analysis and Chemometrics, Department of Chemistry, Federal University of Paraná, P.O. Box: 19032, Curitiba, PR 81531-980, Brazil. Electronic address:
Yerba mate, a key crop in South America, is prized for its pleasant taste and high organoleptic quality, often linked to lower branch content. To quantify branch content and authenticate high-quality samples (less than 30 % m/m branch content), a Chemometrics-assisted Color Histogram-based Analytical System (CACHAS) was employed. Using Hue-Saturation-Value (HSV) histograms, Partial Least Squares (PLS) demonstrated excellent predictive performance, achieving a root mean square error (RMSEP) of 4.
View Article and Find Full Text PDFAppl Ergon
September 2025
NHS Education for Scotland, Edinburgh, United Kingdom; Staffordshire University, Stafford, United Kingdom; University of Glasgow, Glasgow, United Kingdom. Electronic address:
Purpose: To share key learnings from the assessment of a COVID-19 vaccination system in Scotland using a Human Reliability Analysis (HRA) approach.
Method: Project data were collected in February 2021 in NHS Ayrshire and Arran (NHSAA) - the regional health authority - using document analysis (Service Delivery Manual, 2020), observations (2 site visits), and workshops (n = 8, with 26 participants). The Systematic Human Error Reduction and Prediction Approach (SHERPA) is a framework for human reliability analysis that can be used as part of a safety assessment or safety case to determine whether the system is 'safe enough' and provide recommendations to improve safety by mitigating error potential.