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http://dx.doi.org/10.3389/fphar.2023.1274139 | DOI Listing |
CNS Drugs
September 2025
Global Health Neurology Lab, Sydney, NSW, 2150, Australia.
Acute ischemic stroke (AIS) remains a leading cause of mortality and long-term disability globally, with survivors at high risk of recurrent stroke, cardiovascular events, and post-stroke dementia. Statins, while widely used for their lipid-lowering effects, also possess pleiotropic properties, including anti-inflammatory, endothelial-stabilizing, and neuroprotective actions, which may offer added benefit in AIS management. This article synthesizes emerging evidence on statins' dual mechanisms of action and evaluates their role in reducing recurrence, improving survival, and mitigating cognitive decline.
View Article and Find Full Text PDFJ Addict Nurs
September 2025
Cecilie W. Toudahl, MSc, The College of Nursing, University of South Carolina, Columbia, South Carolina.a.
Substance misuse among college students continues to rise, with polysubstance use becoming increasingly common. Alcohol remains the most prevalent substance, with heavy episodic and high-quantity drinking linked to serious consequences, including injuries, assaults, and deaths. Concurrent use of alcohol and cannabis, as well as other illicit drugs, further compounds risks to health, safety, and academic functioning.
View Article and Find Full Text PDFCancer Pathog Ther
September 2025
Department of Medical Oncology, Beijing Key Laboratory of Key Technologies for Early Clinical Trial Evaluation of Innovative Drugs for Major Diseases, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical Colle
Ann Gastroenterol Surg
September 2025
The Japanese Society of Gastroenterological Surgery Tokyo Japan.
Background: Conventional minimally invasive esophagectomy (C-MIE) is the mainstay for locally advanced esophageal cancer. However, the relationship among facility size, risk-adjusted mortality and morbidity in C-MIE remains unclear. This study aims to clarify whether C-MIE should be consolidated into high-volume centers in Japan.
View Article and Find Full Text PDFJ Robot Surg
September 2025
Department of Orthopedic Surgery, Orthopedic and Rheumatology Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH, A4144195, USA.
Robotic-assisted total joint arthroplasty (RA-TJA) is projected to account for 70% of all arthroplasties by 2030, yet its economic value and operational efficiency have yet to be thoroughly synthesized. While early literature emphasized technical precision, evolving payment models and implementation costs have shifted focus toward cost-effectiveness and workflow integration. To evaluate the economic and institutional viability of RA-TJA by synthesizing available evidence on capital costs, perioperative expenses, learning curves, throughput, and long-term adoption trends.
View Article and Find Full Text PDF