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Objective: There are scarce data comparing Parkinson's disease (PD) and Progressive Supranuclear Palsy (PSP) in social cognition (SC). We aimed to compare patients with PSP and PD in SC.
Methods: We included three groups: PD (n = 18), PSP (n = 20) and controls (n = 23). Participants underwent neuropsychological exams, including the mini-version of the Social and Emotional Assessment, which is composed of the facial emotion recognition test (FERT) and the modified faux-pas (mFP) test, which assesses Theory of Mind (ToM).
Results: Patients with PD scored lower than controls in the FERT, but not in the mFP test. Patients with PSP performed worse than controls in both the mFP and FERT. PD and PSP groups did not differ in the FERT, but PSP performed worse than PD in the mFP test. The mFP test distinguished PSP from PD with 89% accuracy.
Conclusion: The assessment of ToM may contribute to the differentiation between PD and PSP.
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http://dx.doi.org/10.1093/arclin/acad081 | DOI Listing |
Int J Biol Macromol
September 2025
Department of Biochemistry and Biotechnology, Council of Scientific and Industrial Research (CSIR) - Central Leather Research Institute, Chennai, Tamil Nadu 600020, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address:
Mussel foot protein-5 (mfp-5) is a key biological macromolecule responsible for the remarkable ability of mussels to adhere to wet and diverse surfaces. While the function of L-3,4-dihydroxyphenylalanine (Dopa) in underwater adhesion is well-characterised, the structural and functional role of hydroxyproline (Hyp) in mfp-5 remains underexplored, largely due to challenges in achieving site-specific dual post-translational modifications (PTMs). In this study, we employed residue-specific genetic code expansion strategies to incorporate either Dopa or Hyp into mfp-5 and systematically analyzed their effects on liquid-liquid phase separation (LLPS), redox stability, and interfacial interactions.
View Article and Find Full Text PDFJ Med Internet Res
July 2025
Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jingwu Weiqi Rd, Jinan, 250021, China, 86 13853121769.
Background: Pancreatic ductal adenocarcinoma (PDAC) and mass-forming pancreatitis (MFP) share similar clinical, laboratory, and imaging features, making accurate diagnosis challenging. Nevertheless, PDAC is highly malignant with a poor prognosis, whereas MFP is an inflammatory condition typically responding well to medical or interventional therapies. Some investigators have explored radiomics-based machine learning (ML) models for distinguishing PDAC from MFP.
View Article and Find Full Text PDFMalays Fam Physician
June 2025
MD, MMED, Fellowship in Nephrology Nephrology Department, Hospital Kuala Lumpur, Jalan Pahang, Kuala Lumpur, Malaysia.
Introduction: The pilot project Nephrology Liaison Clinic, initiated in 2019 at Klinik Kesihatan Sentul, integrates nephrology services into primary care. Managed by primary care physicians with periodic nephrologist input, this project aims to enhance early intervention and reduce tertiary care burdens.
Methods: In this retrospective study, the clinical outcomes of patients enrolled from 2019 to 2021 were analysed.
J Exp Clin Cancer Res
July 2025
Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, 39 Huaxiang Road, Tiexi District, Shenyang City, 110022, Liaoning Province, China.
Background: M2 macrophages are known to be involved in tumorigenesis. However, the mechanism by which they promote tumor progression in endometrial cancer (EC) remains largely unknown. Kynureninase (KYNU) has been found to be associated with the progression of various tumors, but research on endometrium is limited to embryo transfer.
View Article and Find Full Text PDFAm Heart J
December 2025
University of Washington-Harborview Center for Prehospital Emergency Care, University of Washington, Seattle, WA.
Cardiogenic shock (CS) is a state of critical end-organ hypoperfusion due to reduced cardiac output. Patients with acute myocardial infarction-related cardiogenic shock (AMI-CS) have a survival to discharge of only 50%-60%. Mechanical circulatory support (MCS) devices are intended to support the failing heart and improve perfusion.
View Article and Find Full Text PDF