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Objective: To determine associations between post-emergency department (ED) management pathways and downstream opioid prescriptions in patients seeking care for incident neck and/or back pain.
Patients And Methods: We identified patients seeking first-time ED care for neck and/or back pain from January 1, 2013, through November 6, 2017. We reported demographic characteristics and opioid prescriptions across management pathways using descriptive statistics and assessed the relative risk of any opioid prescription 12 months post-ED visit among 5 different post-ED management pathways using Poisson regression adjusted for patient demographic characteristics.
Results: Within 12 months after the index ED visit, 58.0% (n=10,949) were prescribed an opioid, with most patients prescribed an opioid within the first week (average daily morphine milligram equivalents of 6.8 mg (SD 9.6 mg). The morphine milligram equivalents decreased to 0.7 mg (SD 8.2 mg) by week 4 and remained consistently less than 1 mg between week 4 and 12 months. Compared with the ED to primary care provider pathway, the relative risk of opioid prescription between 7 days and 12 months after the index ED visit was similar for the ED to physical therapy pathway, higher for both the ED to hospital admission or repeat ED visit pathway (30% increase; relative risk (RR), 1.3; 95% CI, 1.17-1.44) and the ED to specialist pathway (19% increase; RR, 1.19; 95% CI, 1.07-1.33), and lower in the ED with no follow-up visits pathway (41% decrease; RR, 0.59; 95% CI, 0.54-0.65).
Conclusion: In general, more conservative care was associated with lower opioid prescription rates, and escalated care was associated with higher opioid prescription rates.
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http://dx.doi.org/10.1016/j.mayocpiqo.2023.08.001 | DOI Listing |
Cancer Med
September 2025
Department of Biostatistics & Data Science, School of Public and Population Health, University of Texas Medical Branch, Galveston, Texas, USA.
Introduction: Chronic pain is a major but modifiable contributor to poor quality of life among long-term cancer survivors. With growing concern over opioid-related risks, gabapentinoids have emerged as a safer alternative, though evidence comparing their effectiveness remains limited.
Methods: We conducted a retrospective cohort study using SEER-MHOS linked data (1998-2021) to examine pain interference and health-related quality of life (HRQoL) among 24,651 cancer survivors.
J Law Med Ethics
September 2025
Dalla Lana School of Public Health, https://ror.org/03dbr7087University of Toronto, Canada.
The opioid overdose crisis has become a global public health emergency, claiming more than 100,000 lives each year. In North America, shifting opioid prescribing practices in response to the crisis have profoundly affected people living with chronic pain, who now face reduced access to prescription opioids. Against this backdrop, pain stakeholders have become increasingly active in policymaking arenas to shape how opioids and pain are understood.
View Article and Find Full Text PDFCancer
September 2025
Department of Biostatistics, Brown University School of Public Health, Providence, Rhode Island, USA.
Background: Opioid exposure during cancer therapy may increase long-term unsafe opioid prescribing. This study sought to determine the rates of coprescription of benzodiazepine and opioid medications and new persistent opioid use after surgical treatment of early-stage cancer.
Methods: A retrospective cohort study was conducted among a US veteran population via the Veterans Affairs Corporate Data Warehouse database.
BMJ Open
September 2025
Faillace Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, USA.
Introduction: Exposure to prescription opioids following traumatic injury can increase the risk of developing tolerance, persistent opioid use and opioid use disorder. The mechanisms underlying opioid tolerance or dependence are not well understood, and no biomarkers predict risk. Opioid exposure causes epigenetic modifications, including alterations in microRNA (miRNA) expression.
View Article and Find Full Text PDFSurgery
September 2025
Department of Surgery, University of Michigan Medical School, Ann Arbor, MI; Center for Healthcare Outcomes and Policy, University of Michigan, Ann Arbor, MI.
Background: Although procedure-specific guidelines have been established for postoperative opioid prescribing in the elective setting, it is unknown to what extent prescriptions in the emergency setting adhere to these standards. Variation in opioid prescribing for emergency general surgery patients may represent context-appropriate deviation or an opportunity for improved stewardship.
Methods: Leveraging data from a statewide Acute Care Surgery collaborative, we identified patients undergoing 4 common procedures in the emergency setting: laparoscopic appendectomy, laparoscopic cholecystectomy, emergency hernia repair, and open colectomy.