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http://dx.doi.org/10.1513/AnnalsATS.202307-618ED | DOI Listing |
Front Pediatr
August 2025
Pediatrics Department, Kazan State Medical University of the Ministry of Health of the Russian Federation, Kazan, Russia.
Background: Acid sphingomyelinase deficiency (ASMD) type A/B, a rare lysosomal storage disorder caused by biallelic mutations in the SMPD1 gene, presents with variable visceral and neurological manifestations. Arnold-Chiari malformation is a structural defect of the cerebellum and brainstem with distinct pathogenesis and clinical course. To our knowledge, the coexistence of these two conditions has not been previously reported.
View Article and Find Full Text PDFCureus
September 2025
Oncologic Sciences, University of South Florida Morsani College of Medicine, Tampa, USA.
The spinal cord is an organ capable of sending and receiving a lot of biological and electrical information. It is not just a sending and receiving channel, but a living structure capable of autonomously processing the afferent and efferent notifications with which it comes into contact. The osteopathic neurological model includes the concept of facilitation of the spinal segment, that is, a reflex arc that is established in a spinal segment between two visceral and/or somatic structures, creating a loop of chronicity.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Guangxi University of Chinese Medicine, Nanning, Guangxi Zhuang Autonomous Region, China.
Background: This study investigated the efficacy of moxibustion with aconite cake combined with earlobe acupressure in alleviating anxiety and depression in newly diagnosed human immunodeficiency virus patients.
Methods: Ninety eligible patients from the Affiliated Ruikang Hospital of Guangxi University of Chinese Medicine were randomly divided into an intervention group and a control group of 45 each. The control group received conventional care, while the intervention group received the combined therapy.
Oncol Res
September 2025
Department of Oncology, Affiliated Hospital of Guilin Medical University, Guilin, 541001, China.
Background: The use of third-generation different tyrosine kinase inhibitors (TKIs) is considered the most effective option for treating advanced non-small cell lung cancer (aNSCLC) with epidermal growth factor receptor (EGFR) mutations. However, there is limited information on the efficacy and safety of aumolertinib in patients remains these cases.
Methods: The clinical records of patients receiving aumolertinib as first-line therapy across four hospitals in the Guangxi Zhuang Autonomous Region from April 2020 to December 2021 were retrospectively analyzed, using progression-free survival (PFS) as the primary endpoint and overall survival (OS) representing the secondary endpoint.
Environ Pollut
September 2025
Department of Geriatrics, Tianjin Medical University General Hospital, Anshan Road No. 154, Tianjin, 300052, China; Key Laboratory of Post-Trauma Neuro-Repair and Regeneration in Central Nervous System, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin Neurol
This study systematically investigated the association between triclosan (TCS) exposure and Alzheimer's disease (AD) risk via integrated bioinformatics approaches. TCS-AD-related genes were identified using bioinformatics tools and public databases, followed by the screening of key genes through multi-model machine learning algorithms (LASSO, SVM-RFE, RF) to mitigate random errors in small sample sizes. DRD2 was confirmed as the most robust core gene by LASSO confidence interval analysis and SHAP evaluation, while APP and SLC6A3 were validated through cross-method intersection.
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