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: Local anesthetics administered via epidural catheters have evolved from intermittent top-ups to simultaneous administration of continuous epidural infusion (CEI) and patient-controlled epidural analgesia (PCEA) using the same device. The latest programmed intermittent epidural bolus (PIEB) model is believed to create a wider and more even distribution of analgesia inside the epidural space. The switch from CEI + PCEA to PIEB + PCEA in our department began in 2018; however, we received conflicting feedback regarding workload from the quality assurance team. This study aimed to investigate the benefits and drawbacks of this conversion, including the differences in acute pain service (APS) staff workload, maternal satisfaction, side effects, and complications before and after the changeover. : Items from the APS records included total delivery time, average local anesthetic dosage, and the formerly mentioned items. The incidence of side effects, the association between the duration of delivery and total dosage, and hourly medication usage in the time subgroups of the CEI and PIEB groups were compared. The staff workload incurred from rescue bolus injection, catheter adjustment, and dosage adjustment was also analyzed. : The final analysis included 214 and 272 cases of CEI + PCEA and PIEB + PCEA for labor analgesia, respectively. The total amount of medication and average hourly dosage were significantly lower in the PIEB + PCEA group. The incidences of dosage change, manual bolus, extra visits per patient, and lidocaine use for rescue bolus were greater in the PIEB + PCEA group, indicating an increased staff workload. However, the two groups did not differ in CS rates, labor time, maternal satisfaction, and side effects. : This study revealed that while PIEB + PCEA maintained the advantage of decreasing total drug doses, it inadvertently increased the staff burden. Increased workload might be a consideration in clinical settings when choosing between different methods of PCEA.
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http://dx.doi.org/10.3390/medicina59091579 | DOI Listing |
Drug Des Devel Ther
August 2025
Department of Anesthesiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People's Republic of China.
Purpose: Programmed intermittent epidural bolus (PIEB) is a novel epidural anesthesia technique for video-assisted thoracic surgery (VATS). However, the optimal setting of the PIEB parameters remains to be determined. This study aimed to determine the optimal time interval for the PIEB regimen of 10 mL ropivacaine 0.
View Article and Find Full Text PDFCan J Anaesth
June 2025
Department of Anesthesiology, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Japan.
Purpose: The umbilical analgesic concentrations after using programmed intermittent epidural bolus (PIEB) and patient-controlled epidural analgesia (PCEA) without continuous infusion are unknown. We aimed to characterize umbilical ropivacaine and fentanyl concentrations and examine their influence on neonatal conditions at delivery.
Methods: We prospectively studied 50 parturients with singleton pregnancies who received combined spinal-epidural analgesia using PIEB (7 mL every 45 min) and PCEA (7 mL per bolus; lockout interval: 15 min) with 0.
Int J Obstet Anesth
August 2025
Division of Anesthesia, Intensive Care, and Pain, Tel-Aviv Medical Center, Tel-Aviv University, Affiliated to the Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Background: Studies suggest that programmed intermittent epidural bolus (PIEB) with patient-controlled epidural analgesia (PCEA) for labor epidural analgesia maintenance provides better analgesia, greater maternal mobility during labor, and improved obstetric outcomes compared with continuous epidural infusion (CEI) with PCEA. However instrumental vaginal delivery rates with PIEB/PCEA remain underreported.
Methods: Following implementation of PIEB/PCEA in our institution, a retrospective study was conducted comparing outcomes with CEI/PCEA (July to December 2020) vs.
Indian J Psychiatry
December 2024
Department of Psychiatry, Government Medical College and Hospital, Chandigarh, India.
Background: Postpartum depression (PPD) is a serious concern with multifactorial etiology. Association between prenatal anxiety, pain, and depression has been theorized.
Aim: In this randomized controlled trial, we studied the effect of pain relief by combined spinal epidural (CSE) and other factors influencing PPD.
Drug Des Devel Ther
December 2024
Department of Anesthesia, Jiaxing University Affiliated Women and Children Hospital, Jiaxing City, People's Republic of China.
Background: Interval time, defined as the period of time that effective analgesia can be achieved without the need for patient-controlled epidural analgesia (PCEA), has been investigated as an important parameter for the design of programmed intermittent epidural bolus (PIEB) approaches to labor analgesia. PCEA approaches offer flexibility in the management of labor-related pain while minimizing the risk of patient overdose. Here, the optimal interval between PIEB boluses of 0.
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