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http://dx.doi.org/10.1097/PEP.0000000000001051 | DOI Listing |
J Psychopharmacol
September 2025
Department of Psychiatry and Behavioral Sciences, Center for Psychedelics and Consciousness Research, Johns Hopkins University, Baltimore, MD, USA.
As psychedelic clinical trials expand in scale and influence, foundational challenges in trial design have come into sharper focus. In this commentary, we examine three interrelated issues: 1) the failure of blinding in psychedelic trials, 2) the potential of alternate controls including dose-response designs as an empirical workaround, and 3) the persistent ambiguity surrounding psychosocial control conditions. We argue that efforts to preserve traditional placebo-controlled frameworks are often inadequate due to the unmistakable subjective effects of psychedelics and the therapeutic relevance of those effects themselves.
View Article and Find Full Text PDFAnn Dyslexia
August 2025
AIM Institute for Learning and Research, Conshohocken, PA, United States.
Policy change around dyslexia has accelerated in recent years, yet much of it still lags behind contemporary scientific understanding. Many statutes rely on categorical models that frame dyslexia as a fixed, phonological disorder and prescribe narrowly defined interventions. This commentary calls for a shift from policy proliferation to targeted refinement, advancing developmentally grounded, scientifically accurate legislation that is feasible to implement at scale.
View Article and Find Full Text PDFRes Involv Engagem
August 2025
Department of Optometry and Visual Sciences, School of Health and Psychological Sciences, City St George's, University of London, London, UK.
Background: Awareness of the importance of patient and public involvement (PPI) in ophthalmology research is growing, ensuring studies align with patient priorities and experiences. However, there is limited literature exploring the practicalities and details of how PPI may be conducted within this field. In this case study of PPI within an ophthalmological research project, we aim to provide a transparent, in-depth illustration of how PPI was implemented and helped to shape the Acceptability of Geographic Atrophy INjections (AGAIN) study.
View Article and Find Full Text PDFJ Am Coll Emerg Physicians Open
August 2025
Department of Emergency Medicine, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
Objectives: Physician burnout in emergency medicine has serious consequences. An underrecognized stressor for physicians may be the emergency department (ED) environment itself. EDs can be noisy and chaotic, lack natural light, and have challenging layouts that create patient care and safety concerns.
View Article and Find Full Text PDFFront Pediatr
June 2025
Expert Microbiology Unit, Department of Health Security, National Institute for Health and Welfare, Helsinki, Finland.
[This corrects the article DOI: 10.3389/fped.2024.
View Article and Find Full Text PDF