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It is a dominant dictum in ethics that 'ought implies can' (OIC): if an agent morally ought to do an action, the agent must be capable of performing that action. Yet, with current technological developments, such as in direct-to-consumer genomics, big data analytics and wearable technologies, there may be reasons to reorient this ethical principle. It is our modest aim in this article to explore how the current wave of allegedly disruptive innovation calls for a renewed interest for this dictum. As an effect of prevention and prediction oriented technological innovation, an increased focus on assumedly controllable lifestyle risks may be anticipated. For lay people who might turn into patients, this may entail a reinforced behavior-based individual responsibilisation. Holding on to the OIC dictum, such responsibilisation seems to require that individuals can actually control what is framed as 'lifestyle risks' when there is not always a reliable consensus about what one should do. As such, reference to OIC may be mobilised in function of a political task of designing institutions so as to enable such choice and control.
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http://dx.doi.org/10.1136/jme-2023-108946 | DOI Listing |
Soc Forces
September 2025
Department of Sociology, University of Minnesota, 267 19th Ave S, Minneapolis, MN 55455, United States of America.
In his path-breaking monograph, , Melvin Kohn reasoned that parents prepare their children for the same conditions of work that they themselves experience. Kohn and his colleagues' research focused on the influence of parental self-direction at work on parental child-rearing values and practices, as well as the self-directed values of children. The intergenerational transmission of occupational self-direction from parents to the succeeding generation of adult children, strongly implied by Kohn's analysis, has not been empirically tested.
View Article and Find Full Text PDFMicrobiol Spectr
August 2025
Department of Microbiology and Cell Science, Institute of Food and Agricultural Science, University of Florida, Gainesville, Florida, USA.
Lysine acetylation is a post-translational modification that occurs in all domains of life, highlighting its evolutionary significance. Previous genome comparison identified three Gcn5-related N-acetyltransferase (GNAT) family members as lysine acetyltransferase homologs (Pat1, Pat2, and Elp3) and two deacetylase homologs (Sir2 and HdaI) in the halophilic archaeon , with and proposed as a synthetic lethal gene pair. Here, we advance these findings by performing single and double mutagenesis of with the and lysine acetyltransferase gene homologs.
View Article and Find Full Text PDFTrop Anim Health Prod
June 2025
Department of Animal Science, Faculty of Agriculture, Eskişehir Osmangazi University, Eskişehir, 26160, Türkiye.
This study aimed to investigate genetic bottleneck effects and migration events among four native Turkish sheep breeds, namely Güney Karaman (GKR), Karakaş (KRK), Kangal (KNG), and Norduz (NRD). After genotyping a total of 120 animals with 28 highly polymorphic microsatellite loci, the genetic bottleneck was assessed by the Wilcoxon test under different mutation models, while population splits and migration events were investigated by the TreeMix algorithm. Wilcoxon sign rank test under the two-phased mutation model (TPM) and the mode-shift indicator based on the distribution of allele frequencies evidenced a lack of genetic bottleneck in four Anatolian sheep breeds.
View Article and Find Full Text PDFCell Mol Life Sci
June 2025
Departament de Biomedicina, Unitat de Biologia Cel·lular, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.
Ever since their discovery five decades ago, annexins have been implicated in membrane-related events along endo- and exocytic pathways. Over the years, structural, biochemical and cell imaging studies have revealed that annexins facilitate the organization of membrane domains to allow the formation of tight interactions between membranes destined to fuse. Yet, a comprehensive understanding that would elucidate the molecular characteristics, specific pathways and modes of action in relation to membrane trafficking events for all 12 human annexins is still lacking.
View Article and Find Full Text PDFPhys Chem Chem Phys
June 2025
Kenneth S. Pitzer Center for Theoretical Chemistry, Department of Chemistry, University of California, Berkeley, California 94720, USA.
Accurate prediction of barrier heights and reaction energies is of paramount importance for reaction kinetics. For computational efficiency, such calculations are typically performed with density functional theory (DFT) methods, with accuracy that depends critically on the choice of functional. The RDB7 dataset (K.
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