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Purpose: The purpose of this American Urological Association (AUA) Guideline amendment is to provide a useful reference on the effective evidence-based management of male lower urinary tract symptoms secondary/attributed to BPH (LUTS/BPH).
Materials And Methods: The Minnesota Evidence Review Team searched Ovid MEDLINE, the Cochrane Library, and the Agency for Healthcare Research and Quality (AHRQ) database to identify studies relevant to the management of BPH. The guideline was updated in 2023 to capture eligible literature published between September 2020 and October 2022. When sufficient evidence existed, the body of evidence was assigned a strength rating of A (high), B (moderate), or C (low) for support of Strong, Moderate, or Conditional Recommendations. In the absence of sufficient evidence, additional information is provided as Clinical Principles and Expert Opinions.
Results: The BPH amendment resulted in changes to statements/supporting text on combination therapy, photoselective vaporization of the prostate (PVP), water vapor thermal therapy (WVTT), laser enucleation, and prostate artery embolization (PAE). A new statement on temporary implanted prostatic devices (TIPD) was added. In addition, statements on transurethral needle ablation (TUNA) and transurethral microwave thermotherapy (TUMT) were removed and information regarding these legacy technologies was added to the background section. References and the accompanying treatment algorithms were updated to align with the updated text.
Conclusion: This guideline seeks to improve clinicians' ability to evaluate and treat patients with BPH/LUTS based on currently available evidence. Future studies will be essential to further support these statements to improve patient care.
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http://dx.doi.org/10.1097/JU.0000000000003698 | DOI Listing |
Urol Oncol
September 2025
Nutritional, Genes and Human Disease Laboratory, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, Bangladesh. Electronic address:
Background: Understanding the mutational landscape is critical for elucidating the molecular mechanisms driving cancer progression. This study aimed to profile somatic mutations in bladder cancer patients (N=7) from Bangladesh to provide insights into the genetic alterations underlying this malignancy.
Methods: We performed targeted sequencing of 50 oncogenes and tumor suppressor genes using the Ion AmpliSeq Cancer Hotspot Panel v2 on tumor and matched blood samples from seven bladder cancer patients.
Intern Med
September 2025
Department of Infectious Diseases, Fukuoka City Hospital, Japan.
Staphylococcus saprophyticus primarily colonizes the lower gastrointestinal tract; however, infections from this site are rarely reported. A 77-year-old man developed an ischemic stroke and fever. Blood cultures showed S.
View Article and Find Full Text PDFNihon Shokakibyo Gakkai Zasshi
September 2025
Second Department of Internal Medicine, Osaka Medical and Pharmaceutical University.
Mycoplasma genitalium can cause urinary tract infections and nonchlamydial, nongonococcal urethritis. Recent studies have suggested that M. genitalium is associated with sexually transmitted diseases, particularly among men who have sex with men.
View Article and Find Full Text PDFEcotoxicol Environ Saf
September 2025
Department of Nephrology, Chang Gung Memorial Hospital, Keelung Branch, 222, Mai-Chin Road, Keelung 20401, Taiwan; College of Medicine, Chang Gung University, No. 259, Wenhua 1st Rd., Guishan Dist, Taoyuan City, Taipei 33302, Taiwan; Community Medicine Research Center, Chang Gung Memorial Hospital,
Per- and polyfluoroalkyl substances (PFAS) are a large class of synthetic chemicals widely used in industrial and consumer applications, known for their environmental persistence, bioaccumulation, and potential toxicity. Mounting toxicological evidence suggests that the kidney is a primary target organ for PFAS accumulation, yet human data regarding compound-specific renal effects remain limited. In this community-based prospective cohort study, we investigated the associations between serum PFAS concentrations and renal outcomes in 257 adults, including 48 with chronic kidney disease (CKD) and 209 with normal kidney function at baseline.
View Article and Find Full Text PDFClin Nutr
August 2025
Department of Pediatrics, Division of Gastroenterology, Erasmus MC University Medical Center Sophia Children's Hospital, Rotterdam, the Netherlands. Electronic address:
Background & Aims: Parenteral nutrition (PN) dependency in patients with intestinal failure (IF) can lead to complications including liver disease. Therefore, IF management strives to wean patients off PN. In adult IF, chronic cholestasis is predicted by the functional gut parameters citrulline (CIT) and enteroendocrine fibroblast growth factor 19 (FGF19), which inhibits hepatic bile salt synthesis.
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