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Obsessive-compulsive disorder (OCD) is a prevalent and highly disabling condition, characterized by a range of phenotypic expressions, potentially associated with geo-cultural differences. This article aims to provide an overview of the published studies by the International College of Obsessive-Compulsive Spectrum Disorders, in relation to the Snapshot database which has, over the past 10 years, gathered clinical naturalistic data from over 500 patients with OCD attending various research centers/clinics worldwide. This collaborative effort has provided a multi-cultural worldwide perspective of different socio-demographic and clinical features of patients with OCD. Data on age, gender, smoking habits, age at onset, duration of illness, comorbidity, suicidal behaviors, and pharmacological treatment strategies are presented here, showing peculiar differences across countries.
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http://dx.doi.org/10.1017/S1092852923002432 | DOI Listing |
Indian J Psychiatry
August 2025
Department of Psychiatry, Institute of Psychiatry-Centre of Excellence, Kolkata, West Bengal, India.
Supratherapeutic dosing of selective serotonin reuptake inhibitors (SSRIs) in obsessive-compulsive disorder (OCD) is an area of clinical interest, particularly for treatment-resistant cases. Standard SSRI doses often provide insufficient symptom relief, prompting clinicians to explore higher-than-recommended doses. Evidence suggests that supratherapeutic dosing can enhance serotonergic activity, potentially improving treatment response.
View Article and Find Full Text PDFOphthalmol Sci
July 2025
Illinois Eye and Ear Infirmary, Department of Ophthalmology, University of Illinois at Chicago, Chicago, Illinois.
Purpose: To validate a custom FIJI (ImageJ) program for more reproducible, faster curvilinear periorbital measurements, as compared with 2 custom artificial intelligence-based tools.
Design: Combined technical validation and method comparison study.
Subjects: Front-facing photographs of 45 cleft palate syndromic patients.
Psychophysiology
September 2025
Department of Human Medicine, Institute for Systems Medicine, MSH Medical School Hamburg, Hamburg, Germany.
Obsessive-compulsive disorder (OCD) has been associated with altered performance monitoring, reflected in enhanced amplitudes of the error-related negativity in the event-related potential. However, this is not specific to OCD, as overactive error processing is also evident in anxiety. Although similar neural mechanisms have been proposed for error and feedback processing, it remains unclear whether the processing of errors as indexed by external feedback, reflected in the feedback-related negativity (FRN), is altered in OCD.
View Article and Find Full Text PDFNeuropsychobiology
September 2025
Introduction: There has been an increasing focus on sex differences in bipolar disorder in recent years, yet much remains to be understood about their impact on clinical characteristics and treatment approaches. The aim of this study is to identify sex differences that could alter diagnosis and treatment strategies, potentially improving patient compliance and outcomes.
Methods: This retrospective study analysed data from interviews with 340 participants (171 men, 169 women; ages ranging from 18 to 82 years) from the BIPFAT/BIPLONG study at the specialised outpatient centre for bipolar disorder at the Medical University of Graz, Austria.
Clin EEG Neurosci
September 2025
Department of Psychiatry, NPI Brain Hospital, Uskudar University, Istanbul, Turkey.
IntroductionObsessive-compulsive disorder (OCD) affects 1.1-1.8% of the population, and adult females are more likely to suffer from it.
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