Lipids and Terpenoids from the Deep-Sea Fungus R22 and Their Antagonism against Two Wheat Pathogens.

Five new lipids, tricholixins A-E (-), and two known terpenoids, brasilane A () and harzianone A (), were discovered from a deep-sea strain (R22) of the fungus isolated from the cold seep sediments of the South China Sea. Their structures and relative configurations were identified by meticulous analysis of MS and IR as well as NMR data. The absolute configuration of was ascertained by dimolybdenum-induced ECD data in particular. Compounds and represent the only two new butenolides from marine-derived , and they further add to the structural diversity of these molecules. Although has been reported from a basidiomycete previously, it is the first brasilane aminoglycoside of origin. During the assay against wheat-pathogenic fungi, both and inhibited with an MIC value of 25.0 μg/mL, and suppressed with an MIC value of 12.5 μg/mL. Moreover, the three isolates also showed low toxicity to the brine shrimp .