Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Purpose: To systematically review and report the rate of exudative progression over time in patients with nonexudative macular neovascularization (MNV) in age-related macular degeneration (AMD).
Design: Systematic review with prevalence meta-analyses and individual participant meta-analysis.
Methods: We searched 10 literature databases on March 26, 2023, for studies of consecutive patients with treatment-naïve nonexudative MNV in AMD. The primary outcome of interest was time from diagnosis to exudative progression. We conducted meta-analyses on the prevalence of exudative progression at 1 and 2 years. Where possible, we extracted individual participant data from studies and conducted an individual participant meta-analysis and explored the exudative progression using a time-to-event curve.
Results: We identified 16 eligible studies with a total of 384 eyes with nonexudative MNV. Exudative progression had occurred in 20.9% (95% CI 13.1%-29.8%) of eyes at 1 year and in 30.7% (95% CI 21.8%-40.4%) at 2 years. Similar results were observed in the individual participant meta-analysis, showing exudative progression in 18.9% (95% CI 13.5%-26.3%) of eyes at 1 year and 31.3% (95% CI 24.2%-40.0%) at 2 years. Risk factors for a fast exudative progression were the presence of subretinal lipid globules, large MNV areas, rapid MNV growth, growth in pigment epithelium detachment height and width, appearance of a branching pattern, and development of a hyporeflective halo around the MNV.
Conclusions: Nonexudative MNVs in AMD are at high risk of exudative progression. Recognition of these lesions may allow for better individualized follow-up regimens in which closer monitoring may facilitate earlier diagnosis of exudative progression.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ajo.2023.08.020 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Morel-Lavallée lesion: What you need to know.
J Trauma Acute Care Surg
September 2025
From the Department of Surgery, Center for Trauma and Critical Care, George Washington University, Washington, DC.
Abstract: The Morel-Lavallée lesion (MLL) is a rare closed degloving injury resulting from traumatic shearing forces that separate subcutaneous tissue from underlying fascia, creating a cavity filled with blood, lymph, and inflammatory exudate. Typically occurring in regions where skin can glide significantly over rigid structures, such as the thigh, MLLs present as fluctuant, boggy, sometimes painful lesions, which result from disrupted lymphatic and vascular structures. The lesion evolves through an inflammatory cascade leading to eventual encapsulation by dense fibrotic tissue.
View Article and Find Full Text PDFAntidepressant Use and Incidence and Progression of Age-Related Macular Degeneration in a National United States Database.
Am J Ophthalmol
August 2025
Department of Ophthalmology, Virginia Commonwealth University, Richmond, Virginia, USA. Electronic address:
Objective: To evaluate the association between antidepressant use and the risk of developing non-exudative and exudative age-related macular degeneration (AMD), as well as the progression from non-exudative to exudative AMD, in patients using selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), or tricyclic antidepressants (TCAs).
Design: Retrospective clinical cohort study.
Subjects: Patients aged ≥40 years identified from the TriNetX database (October 2004-October 2023).
Inflammation and Necrosis Syndrome in Young Piglets-A Longitudinal Study.
Vet Sci
August 2025
Justus-Liebig-University Giessen, Department of Veterinary Clinical Sciences, Clinic for Swine-Herd Health Management and Molecular Diagnostics, Frankfurter Strasse 112, 35392 Giessen, Germany.
Swine Inflammation and Necrosis Syndrome (SINS) is a simple and non-invasive animal-based health and welfare indicator that combines the clinical observation of bristle loss, swelling, redness, exudation, necrosis and haemorrhage in various parts of the body. It provides a point-of-care measure with direct intervention capability. Several studies from different countries demonstrate its considerable prevalence, particularly among newborn, suckling and weaned piglets.
View Article and Find Full Text PDFMultisystemic Tuberculosis Masquerading as Aggressive Cardiac Tumor Causing Budd-Chiari Syndrome Disseminated to the Brain Resulting in Death of a Six-Year-Old Boy.
Pathogens
August 2025
Radiology Department, Rush University Medical Group, Chicago, IL 60612, USA.
Tuberculosis (TB) is an ancient and re-emerging granulomatous infectious disease that continues to challenge public health. Early diagnosis and prompt effective treatment are crucial for preventing disease progression and reducing both morbidity and mortality. These steps play a vital role in infection control and in lowering death rates at both individual and population levels.
View Article and Find Full Text PDFNext-Generation Wound Healing Materials: Role of Biopolymers and Their Composites.
Polymers (Basel)
August 2025
School of Life Science, Handong Global University, Pohang 37554, Republic of Korea.
The progress in biopolymers and their composites as advanced materials for wound healing has revolutionized therapeutic approaches for skin regeneration. These materials can effectively integrate their inherent biocompatibility and biodegradability with the enhanced mechanical strength and customizable properties of polymers and functional additives. This review presents a detailed investigation of the design principles, classifications, and biomedical applications of biopolymeric composites, focusing on their capabilities to promote angiogenesis, exhibit antimicrobial activities, and facilitate controlled drug delivery.
View Article and Find Full Text PDF