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Deep learning approaches for Image Aesthetics Assessment (IAA) have shown promising results in recent years, but the internal mechanisms of these models remain unclear. Previous studies have demonstrated that image aesthetics can be predicted using semantic features, such as pre-trained object classification features. However, these semantic features are learned implicitly, and therefore, previous works have not elucidated what the semantic features are representing. In this work, we aim to create a more transparent deep learning framework for IAA by introducing explainable semantic features. To achieve this, we propose Tag-based Content Descriptors (TCDs), where each value in a TCD describes the relevance of an image to a human-readable tag that refers to a specific type of image content. This allows us to build IAA models from explicit descriptions of image contents. We first propose the explicit matching process to produce TCDs that adopt predefined tags to describe image contents. We show that a simple MLP-based IAA model with TCDs only based on predefined tags can achieve an SRCC of 0.767, which is comparable to most state-of-the-art methods. However, predefined tags may not be sufficient to describe all possible image contents that the model may encounter. Therefore, we further propose the implicit matching process to describe image contents that cannot be described by predefined tags. By integrating components obtained from the implicit matching process into TCDs, the IAA model further achieves an SRCC of 0.817, which significantly outperforms existing IAA methods. Both the explicit matching process and the implicit matching process are realized by the proposed TCD generator. To evaluate the performance of the proposed TCD generator in matching images with predefined tags, we also labeled 5101 images with photography-related tags to form a validation set. And experimental results show that the proposed TCD generator can meaningfully assign photography-related tags to images.
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http://dx.doi.org/10.1109/TIP.2023.3308852 | DOI Listing |
Int J Cosmet Sci
September 2025
Smart Foods and Bioproducts, AgResearch, Lincoln, New Zealand.
Objective: This study investigated the locations of amino acid modifications within two major human hair keratins (Type I K31 and Type II K85) with probable implications for protein and hair structural component integrity. The particular focus was on cysteine modifications that disrupt intra-protein and inter-protein disulphide bonds.
Methods: Human hair was exposed to accelerated, sequential heat or UV treatments, simulating effects resulting from the use of heated styling tools and environmental exposure over a time frame approximating one year.
Front Immunol
September 2025
Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan.
Introduction: Human papillomavirus (HPV) infection has been implicated in autoimmune processes, yet concerns remain about the potential autoimmune risks of HPV vaccination. Juvenile idiopathic arthritis (JIA) is a chronic autoimmune condition that typically manifests in childhood. The relationship between HPV vaccination and the development of JIA remains uncertain.
View Article and Find Full Text PDFRSC Chem Biol
July 2025
Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University Max-von-Laue-Str. 9 D-60438 Frankfurt am Main Germany
Herein we present the rapid development of LH168, a potent and highly selective chemical probe for WDR5, streamlined by utilizing a DEL-ML (DNA encoded library-machine learning) hit as the chemical starting point. LH168 was comprehensively characterized in bioassays and demonstrated potent target engagement at the WIN-site pocket of WDR5, with an EC of approximately 10 nM, a long residence time, and exceptional proteome-wide selectivity for WDR5. In addition, we present the X-ray co-crystal structure and provide insights into the structure-activity relationships (SAR).
View Article and Find Full Text PDFAppl Biosaf
August 2025
Signature Science, LLC, Charlottesville, Virginia, USA.
Screening synthetic nucleic acid orders for sequences of concern is a necessary part of a healthy biosecurity regime, but it exacts costs for nucleic acid providers. Taxonomy is and will remain a critical part of the decision-making process for screening, especially for viral sequences. But, moving forward, the function of a sequence will also be determinative of its level of concern, or lack thereof.
View Article and Find Full Text PDFFront Psychiatry
August 2025
Neurobiology of Stress Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary.
Background: Previous studies indicate that hippocampal (subfield) and amygdala volumes may correlate with specific cognitive functions, coping strategies and emotion regulation. Here, we investigated associations between emotional processing and volumes of hippocampal subfields and amygdala. We focused on depressed patients since emotional dysregulation and hippocampal volume shrinkage are characteristic of them.
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