The negative adipogenesis regulator is transcriptionally regulated by (TIS7) and translationally by its orthologue (SKMc15).

Delta-like homolog 1 (), an inhibitor of adipogenesis, controls the cell fate of adipocyte progenitors. Experimental data presented here identify two independent regulatory mechanisms, transcriptional and translational, by which (TIS7) and its orthologue (SKMc15) regulate levels. Mice deficient in both and (dKO) had severely reduced adipose tissue and were resistant to high-fat diet-induced obesity. Wnt signaling, a negative regulator of adipocyte differentiation, was significantly upregulated in dKO mice. Elevated levels of the Wnt/β-catenin target protein Dlk1 inhibited the expression of adipogenesis regulators and , and fatty acid transporter . Although both and contributed to this phenotype, they utilized two different mechanisms. acted by controlling Wnt signaling and thereby transcriptional regulation of . On the other hand, distinctive experimental evidence showed that Ifrd2 acts as a general translational inhibitor significantly affecting Dlk1 protein levels. Novel mechanisms of regulation in adipocyte differentiation involving and are based on experimental data presented here.