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Perspectives for understanding the brain vary across disciplines and this has challenged our ability to describe the brain’s functions. In this comment, we discuss how emerging theoretical computing frameworks that bridge top-down algorithm and bottom-up physics approaches may be ideally suited for guiding the development of neural computing technologies such as neuromorphic hardware and artificial intelligence. Furthermore, we discuss how this balanced perspective may be necessary to incorporate the neurobiological details that are critical for describing the neural computational disruptions within mental health and neurological disorders.
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http://dx.doi.org/10.1038/s41467-023-40535-z | DOI Listing |
J Anat
September 2025
Department of Biological Sciences (Anthropology), Graduate School of Science, The University of Tokyo, Tokyo, Japan.
The uniqueness of human brain growth and development has been considered promising for its contribution to understanding the origins of the unique human cognitive abilities. Compared with that of chimpanzees, the human endocranium undergoes several characteristic shape changes immediately after birth, which has been termed "endocranial globularization." However, how the brain structures and surrounding neurocranium interact with each other during early development in the context of brain-neurocranium integration remains to be investigated.
View Article and Find Full Text PDFProg Neuropsychopharmacol Biol Psychiatry
September 2025
School of Mathematics and Statistics, Guangdong University of Foreign Studies, Guangzhou, PR China. Electronic address:
Background: Sexual dimorphism in human brain has garnered significant attention in neuroscience research. Although multiple investigations have examined sexual dimorphism in gray matter (GM) functional connectivity (FC), the research of white matter (WM) FC remains relatively limited.
Methods: Utilizing resting-state fMRI data from 569 healthy young adults, we investigated sexual dimorphism in the WM functional connectome.
Brain Res Bull
September 2025
Department of Neuroscience of Disease, Brain Research Institute, Niigata University, Niigata, 951-8585, Japan. Electronic address:
Mutations in the UBE3A gene are responsible for neurodevelopmental disorders (NDDs), including Angelman syndrome (AS), which is characterized by developmental delays, impaired motor coordination, and cognitive disabilities. In recent years, UBE3A mutations have also been linked to autism spectrum disorders (ASD), due to their significant role in synaptic plasticity and cognitive function. Although substantial research has utilized mammalian models, the zebrafish (Danio rerio) provides unique opportunities to investigate gene functions owing to their transparent embryos, rapid development, and suitability for large-scale genetic and behavioral studies.
View Article and Find Full Text PDFNeuroimage
September 2025
Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, Finland; Advanced Magnetic Imaging Centre, Aalto University School of Science, Espoo, Finland. Electronic address:
Cognitive functions emerge from dynamic functional interplay of cortical and subcortical areas that form networks. Preterm birth poses a risk for the formation and functionality of brain networks which may lead to severe brain dysfunctions. Infants born extremely preterm have the highest risk of developing neurocognitive impairments.
View Article and Find Full Text PDFBiol Psychiatry
September 2025
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029 USA; Center for Computational Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10027 USA; The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029 USA; Nash Fami
Background: As we navigate changing social landscapes, maintaining maps of interpersonal dynamics can help guide our choices. Autism spectrum disorder (ASD) is associated with social challenges that may affect the accumulation or application of social information. However, little is known about social cognitive mapping in autistic adults.
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