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We performed a Ga-DOTATOC PET/CT scan on a 25-mo-old female patient who presented with opsoclonus myoclonus ataxia syndrome and had negative initial anatomic imaging. The scan showed a somatostatin receptor-overexpressing cervical tumor in favor of a cervical neuroendocrine tumor, with subsequent histopathologic findings of ganglioneuroblastoma.
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http://dx.doi.org/10.2967/jnmt.123.265776 | DOI Listing |
J Nucl Med
September 2025
Department of Nuclear Medicine, Medical University of Innsbruck, Innsbruck, Austria.
A prospective phase 1/2a pilot study (NCT06155994) was performed at our center to compare the diagnostic performance of cholecystokinin-2 receptor (CCK2R) PET/CT imaging with the Ga-labeled peptide analog DOTA-DGlu-Ala-Tyr-Gly-Trp-(N-Me)Nle-Asp-1-Nal-Phe-NH (Ga-DOTA-MGS5) with that of the reference standard PET/CT. Six patients with advanced medullary thyroid cancer (MTC) and 6 patients with other neuroendocrine tumors (NETs)-4 with gastroenteropancreatic (GEP) NETs and 2 with bronchopulmonary (BP) NETs-were included in the study. All patients had known metastases, documented by Ga-DOTATOC and F-DOPA PET/CT.
View Article and Find Full Text PDFAuris Nasus Larynx
August 2025
Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Department of Head and Neck Oncology and Innovative Treatment, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
The study aimed to highlight the complementary roles of computed tomography (CT), magnetic resonance imaging (MRI), and gallium-68 DOTA-(Tyr³)-octreotide positron emission tomography (Ga-DOTATOC PET) in the diagnosis and treatment of jugulotympanic paragangliomas. We present cases of three patients: a 48-year-old woman with tympanic paraganglioma associated with left facial paralysis (patient 1), a 60-year-old man with asymptomatic jugular paraganglioma (patient 2), and a 73-year-old woman with a small tympanic paraganglioma (patient 3). All patients underwent CT, MRI, and Ga-DOTATOC PET imaging.
View Article and Find Full Text PDFJ Neuroendocrinol
August 2025
Department of Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
We aimed to assess the symptoms and impact on overall survival (OS) from bone metastases (BM) diagnosed on Gallium-68-labelled DOTA tyrosine octreotide positron emission tomography with computed tomography (Ga-DOTATOC-PET/CT) in patients with well-differentiated small intestinal neuroendocrine tumours (Si-NETs). Patients with well-differentiated Si-NETs, who underwent Ga-DOTATOC-PET/CT between 2010 and 2023 at two tertiary referral centres in Sweden, were included. Their number of BM, ≤5 BM versus >5 BM, symptoms and need for analgesics were recorded.
View Article and Find Full Text PDFEur J Nucl Med Mol Imaging
July 2025
Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.
Purpose: Positron range correction (PRC) can mitigate the effect of the larger positron range on the image quality of Gallium-68 (Ga) PET-imaging. The aim of this study is to evaluate the improvement in Ga-PET image quality by applying a tissue-dependent and spatially-variant PRC (TDSV PRC) for Ga in a clinical setting.
Methods: A TDSV PRC technique was developed employing CT-driven segmentation masks of different tissue types (soft tissue, bone, lung) and the corresponding tissue-specific positron range kernels.
Cancer Imaging
July 2025
National Center for Tumor Diseases (NCT), NCT/UCC Dresden, A Partnership Between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz- Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.
Background: Neuroendocrine tumors have increased in prevalence and diversity in recent years and are often diagnosed at metastatic stages. Compared with nonradioactive systemic treatment with somatostatin analogs, peptide receptor radionuclide therapy (PRRT) has shown superior overall survival benefits for well-differentiated neuroendocrine tumor patients. This study aimed to identify biomarkers from Ga‒DOTATOC PET/CT scans to predict survival in patients treated with PRRT in the clinic.
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