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Introduction: Studies show that females have a higher prevalence of osteoarthritis, worse symptoms, but lower rates of joint replacement surgery (JRS). The reason for this remains unknown.
Methods: A database of JRS candidates was created for patients seen in 2019 at an academic center. Demographics, Kellgren-Lawrence grades, symptom duration, visual analogue pain score, Charlson Comorbidity Index, and nonsurgical treatments were collected. Patients who were offered but declined surgery were invited to focus groups. Two independent sample t-tests, Mann-Whitney U tests, and chi-square tests were used for continuous, scored, and categorical variables, respectively, with two-tailed significance <0.05. Qualitative, code-based analysis was performed for the focus groups.
Results: The cohort included 321 patients (81 shoulder, 59 hip, and 181 knee) including 199 females (62.0%). There were no differences in proportions of females versus males who underwent JRS or in nonsurgical treatments. Female shoulder arthritis patients were older, had a higher visual analogue pain score, and had a higher Charlson Comorbidity Index. In focus groups, males prioritized waiting for technology advancements to return to an active lifestyle, whereas females experienced negative provider interactions, self-advocated for treatment, concerned about pain, and believed that their sex affected their treatment.
Discussion: We found equal utilization of JRS at our institution. However, female patients experienced unique barriers to surgery.
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http://dx.doi.org/10.5435/JAAOSGlobal-D-23-00022 | DOI Listing |
J Alzheimers Dis
September 2025
Amsterdam Public Health, Aging & Later life and Personalized Medicine, Amsterdam, the Netherlands.
BackgroundAllostatic load (AL), an umbrella term for the physiological response to chronic stress, is different in women and men. AL has also been associated with all-cause dementia.ObjectiveThe current study investigates if AL clusters differently in men and women, and if these sex-based clusters are associated with all-cause dementia.
View Article and Find Full Text PDFSports Biomech
September 2025
Centre for Interdisciplinary Research in Rehabilitation, Lethbridge-Layton-Mackay Rehabilitation Centre, and the School of Physical and Occupational Therapy, McGill University, Montreal, QC, Canada.
The objective of this study was to compare joint angles and spatiotemporal variables between male and female ice hockey players during skating slap shots. Thirty-nine collegiate players (25 men, 14 women) participated. Kinematic data were collected using a Xsens 17-inertial measurement system.
View Article and Find Full Text PDFJ Vet Pharmacol Ther
September 2025
Elanco Animal Health, Sèvres, France.
Ilunocitinib, a novel Janus kinase inhibitor, is indicated for managing pruritus and skin lesions associated with canine allergic and atopic dermatitis. Pharmacokinetics of ilunocitinib were investigated following single intravenous and oral administrations, both in fed and fasted states. Dose proportionality was assessed using oral doses ranging from 0.
View Article and Find Full Text PDFJ Nurs Manag
September 2025
College of Physical Education, Southwest University, Chongqing, China.
With the increasing participation of women in sports, understanding gender differences in sports injuries has become crucial. This study compares the incidence of sports injuries in male and female athletes through a scope review, analyzes the gender specific patterns of common injury types, summarizes the current situation and challenges of sports injury prevention in female athletes, and proposes targeted clinical practice and research recommendations. This study adopted a scope review design, followed the PRISMA ScR guidelines, and registered with PROSPERO (CRD420251058146).
View Article and Find Full Text PDFRen Fail
December 2025
Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
Biological sex has a profound impact on disease severity, outcomes and diagnosis yet, its role in clinical disease is insufficiently explored. Acute on chronic liver failure (ACLF) is associated with high mortality and multiple organ dysfunctions, where acute kidney injury (AKI) significantly worsens prognosis. Here we investigated the impact of sex on the diagnostic parameters used for severity grading in ACLF.
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