Essential Thrombocythemia and Ischemic Stroke: A Case Series of Five -Positive Patients.

: Essential thrombocythemia (ET) is a chronic myeloproliferative neoplasm characterized by elevated platelet counts and an increased risk of thrombotic events, including ischemic strokes. Materials and : We conducted a retrospective analysis of data from consecutive ischemic stroke patients with ET between March 2014 and February 2023. : This case series describes the clinical presentation, radiological features, and management of five patients with ET-associated ischemic strokes, all harboring the mutation. The diverse radiological findings suggest that both large and small vessel diseases may be influenced by the prothrombotic state induced by ET. A significant elevation in platelet count was observed to correlate with the emergence of new acute infarctions in some cases. : The study highlights combined use of antiplatelet and cytoreductive therapy in preventing secondary stroke events in patients with ET and mutations. The heterogeneity of stroke patterns in this population necessitates a comprehensive understanding of the underlying pathophysiological mechanisms and tailored therapeutic approaches.