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Starvation-inactivated MTOR triggers cell migration via a ULK1-SH3PXD2A/TKS5-MMP14 pathway in ovarian carcinoma. | LitMetric
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Starvation-inactivated MTOR triggers cell migration via a ULK1-SH3PXD2A/TKS5-MMP14 pathway in ovarian carcinoma.

Chiao-Yun Lin , Kai-Yun Wu , Lang-Ming Chi , Yun-Hsin Tang , Huei-Jean Huang , Chyong-Huey Lai , Chi-Neu Tsai , Chia-Lung Tsai

Autophagy

Genomic Medicine Core Laboratory, Chang Gung Memorial Hospital, Taoyuan City, Guishan District, Taiwan.

Published: December 2023

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Article Abstract

AMPK: AMP-activated protein kinase; CHX: cycloheximide; RAD001: everolimus; HBSS: Hanks' balanced salt solution; LC-MS/MS: liquid chromatography-mass spectrometry/mass spectrometry; MMP14: matrix metallopeptidase 14; MTOR: mechanistic target of rapamycin kinase; MAPK: mitogen-activated protein kinase; RB1CC1/FIP200: RB1 inducible coiled-coil 1; PtdIns3P: phosphatidylinositol-3-phosphate; PX: phox homology; SH3: Src homology 3; SH3PXD2A/TKS5: SH3 and PX domains 2A; SH3PXD2A-[6A]: S112A S142A S146A S147A S175A S348A mutant; ULK1: unc-51 like autophagy activating kinase 1.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621272PMC
http://dx.doi.org/10.1080/15548627.2023.2239633DOI Listing

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