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This study was conducted in the Lorestan Province in the west of Iran with two objectives of identifying major environmental variables in spatial risk modeling and identifying spatial risk patches of livestock predation by the Persian leopard. An ensemble approach of three models of maximum entropy (MaxEnt), generalized boosting model (GBM), and random forest (RF) were applied for spatial risk modeling. Our results revealed that livestock density, distance to villages, forest density, and human population density were the most important variables in spatial risk modeling of livestock predation by the leopard. The center of the study area had the highest probability of livestock predation by the leopard. Ten spatial risk patches of livestock predation by the leopard were identified in the study area. In order to mitigate the revenge killing of the leopards, the findings of this study highlight the imperative of implementing strategies by the Department of Environment (DoE) to effectively accompany the herds entering the wildlife habitats with shepherds and a manageable number of guarding dogs. Accordingly, the identified risk patches in this study deserve considerable attention, especially three primary patches found in the center and southeast of Lorestan Province.
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http://dx.doi.org/10.1007/s11356-023-28963-2 | DOI Listing |
Natl Sci Rev
September 2025
Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, China.
Chimeric antigen receptor T (CAR-T)-cell therapy is a promising resolution for solid tumors, but its corresponding clinical translation has been hindered by unsatisfactory therapeutic potency and severe cytokine release syndrome. Herein, tetracycline (Tet)-On inducible human epidermal growth factor receptor 1 (HER1)-targeted CAR-T (Tet-HER1-CAR-T) cells were engineered to enable spatially selective activation at tumor sites by doxycycline (Doxy), which is delivered by pH-responsive stealth liposomal calcium carbonate nanoparticles (Doxy@CaCO-PEG). Compared with the intravenous administration of conventional HER1-CAR-T cells and Tet-HER1-CAR-T cells activated by free Doxy, concurrent intravenous administration of Tet-HER1-CAR-T cells and Doxy@CaCO-PEG leads to the localized tumor activation of Tet-HER1-CAR-T cells and reduced systemic secretion of inflammatory cytokines.
View Article and Find Full Text PDFWellcome Open Res
August 2025
Paul G. Allen School for Global Health, Washington State University, Pullman, Washington, USA.
Arenaviruses and Hantaviruses, primarily hosted by rodents and shrews, represent significant public health threats due to their potential for zoonotic spillover into human populations. Despite their global distribution, the full impact of these viruses on human health remains poorly understood, particularly in regions like Africa, where data is sparse. Both virus families continue to emerge, with pathogen evolution and spillover driven by anthropogenic factors such as land use change, climate change, and biodiversity loss.
View Article and Find Full Text PDFMed Phys
September 2025
Division of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Background: Radiotherapy workflows conventionally deliver one treatment plan multiple times throughout the treatment course. Non-coplanar techniques with beam angle optimization or dosimetrically optimized pathfinding (DOP) exploit additional degrees of freedom to improve spatial conformality of the dose distribution compared to widely used techniques like volumetric-modulated arc therapy (VMAT). The temporal dimension of dose delivery can be exploited using multiple plans (sub-plans) within one treatment course.
View Article and Find Full Text PDFAlcohol Clin Exp Res (Hoboken)
September 2025
Neurodevelopmental Laboratory on Addictions and Mental Health, McLean Hospital, Belmont, Massachusetts, USA.
Background: Examining youth before engagement in risky behaviors may help identify neurobiological signatures that prospectively predict susceptibility to initiating and escalating alcohol and other substance use. Given that frontal and medial temporal (e.g.
View Article and Find Full Text PDFBMC Glob Public Health
September 2025
Kenya Medical Research Institute (KEMRI) - Wellcome Trust Research Programme (KWTRP), Kilifi, Kenya.
Background: Between November 2023 and March 2024, coastal Kenya experienced another wave of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections detected through our continued genomic surveillance. Herein, we report the clinical and genomic epidemiology of SARS-CoV-2 infections from 179 individuals (a total of 185 positive samples) residing in the Kilifi Health and Demographic Surveillance System (KHDSS) area (~ 900 km).
Methods: We analyzed genetic, clinical, and epidemiological data from SARS-CoV-2 positive cases across pediatric inpatient, health facility outpatient, and homestead community surveillance platforms.