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Purpose: Cognitive behavioural therapy (CBT) has been found to be an effective treatment for OCD, but there remains a significant proportion of individuals who fail to show a treatment response. Aerobic exercise has previously been associated with decreases in anxiety and depression, as well as improvements in OCD symptoms in small-scale studies. The purpose of the present research was to use a randomized control trial design to examine the effects of exercise alone and in combination with CBT, on OCD symptoms and secondary symptoms.
Method: 125 participants were randomly assigned to one of four treatment groups: waitlist control, exercise, CBT, and CBT with exercise. OCD symptom severity was measured at four points over the course of treatment, secondary outcome measures were gathered at three points over treatment.
Results: CBT alone and combined with exercise was associated with significantly greater OCD symptom reduction than exercise alone or the control groups. Total exercise frequency predicted OCD symptom reduction in the groups in which exercise was measured. Group membership did not significantly predict reductions in secondary outcome measures.
Conclusion: Exercise frequency, rather than the presence or absence of exercise, appears to predict OCD symptom reduction, as did participation in CBT.
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http://dx.doi.org/10.1016/j.janxdis.2023.102746 | DOI Listing |
Indian J Psychiatry
August 2025
Department of Psychiatry, Institute of Psychiatry-Centre of Excellence, Kolkata, West Bengal, India.
Supratherapeutic dosing of selective serotonin reuptake inhibitors (SSRIs) in obsessive-compulsive disorder (OCD) is an area of clinical interest, particularly for treatment-resistant cases. Standard SSRI doses often provide insufficient symptom relief, prompting clinicians to explore higher-than-recommended doses. Evidence suggests that supratherapeutic dosing can enhance serotonergic activity, potentially improving treatment response.
View Article and Find Full Text PDFPsychophysiology
September 2025
Department of Human Medicine, Institute for Systems Medicine, MSH Medical School Hamburg, Hamburg, Germany.
Obsessive-compulsive disorder (OCD) has been associated with altered performance monitoring, reflected in enhanced amplitudes of the error-related negativity in the event-related potential. However, this is not specific to OCD, as overactive error processing is also evident in anxiety. Although similar neural mechanisms have been proposed for error and feedback processing, it remains unclear whether the processing of errors as indexed by external feedback, reflected in the feedback-related negativity (FRN), is altered in OCD.
View Article and Find Full Text PDFNeuropsychobiology
September 2025
Introduction: There has been an increasing focus on sex differences in bipolar disorder in recent years, yet much remains to be understood about their impact on clinical characteristics and treatment approaches. The aim of this study is to identify sex differences that could alter diagnosis and treatment strategies, potentially improving patient compliance and outcomes.
Methods: This retrospective study analysed data from interviews with 340 participants (171 men, 169 women; ages ranging from 18 to 82 years) from the BIPFAT/BIPLONG study at the specialised outpatient centre for bipolar disorder at the Medical University of Graz, Austria.
Clin EEG Neurosci
September 2025
Department of Psychiatry, NPI Brain Hospital, Uskudar University, Istanbul, Turkey.
IntroductionObsessive-compulsive disorder (OCD) affects 1.1-1.8% of the population, and adult females are more likely to suffer from it.
View Article and Find Full Text PDFBackground: Obsessive-compulsive disorder (OCD) can cause physical complications, and psychiatric treatment sometimes improves these complications. However, it remains unclear whether managing a physical complication can contribute to the improvement of psychiatric symptoms or may alter the trajectory of psychiatric treatment.
Case Presentation: We report on a woman in her 50s with severe, long-standing, treatment-resistant OCD centered on contamination fears and compulsive defecation rituals.