Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: Chemotherapeutic agents such as docetaxel (DTX) can trigger chemotherapy-induced peripheral neuropathy (CIPN), which is characterized by unbearable pain. This study was designed to investigate the analgesic effect and related neuronal mechanism of low-frequency median nerve stimulation (LFMNS) on DTX-induced tactile hypersensitivity in mice.
Methods: To produce CIPN, DTX was administered intraperitoneally 4 times, once every 2 d, to male ICR mice. LFMNS was performed on the wrist area, and the pain response was measured using von Frey filaments on both hind paws. Western blot and immunofluorescence staining were performed using dorsal root ganglion and spinal cord samples to measure the expression of brain-derived neurotrophic factor (BDNF).
Results: Repeated LFMNS significantly attenuated the DTX-induced abnormal sensory response and suppressed the enhanced expression of BDNF in the DRG neurons and spinal dorsal area.
Conclusions: LFMNS might be an effective non-pharmaceutical option for treating patients suffering from CIPN regulating the expression of peripheral and central BDNF.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320447 | PMC |
| http://dx.doi.org/10.19852/j.cnki.jtcm.2023.04.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Nerve Excitability in Asymptomatic Carriers and Amyotrophic Lateral Sclerosis Patients With C9orf72.
Ann Clin Transl Neurol
September 2025
Department of Neurology, Brain Centre Utrecht, University Medical Centre Utrecht, Utrecht, the Netherlands.
Objective: We investigated the effects of C9orf72 mutation carriership on peripheral nerve excitability in asymptomatic individuals from families with a history of C9orf72 amyotrophic lateral sclerosis (ALS) and patients.
Methods: We included 47 asymptomatic individuals from families with a history of C9orf72 ALS, of whom 23 were carriers (C9) and 24 were noncarriers (C9). In addition, 11 C9 and 110 C9 ALS patients and 50 healthy controls participated.
Comparison of arthroscopy- and fluoroscopy-assisted minimally invasive approaches for acetabular fracture repair in dogs: An ex vivo study.
Vet Surg
September 2025
Clinic for Small Animals, University of Veterinary Medicine Hannover, Hannover, Germany.
Objective: To describe and compare arthroscopy-assisted (AA) with fluoroscopy-assisted (FA) minimally invasive plate osteosynthesis (MIPO) for simple transverse acetabular fractures.
Study Design: Ex vivo cadaveric study.
Sample Population: A total of 10 canine cadavers (>20 kg) without coxofemoral joint disease.
Background: Ultrasound measurement of median nerve cross-sectional area (CSA) is widely used in carpal tunnel syndrome (CTS) diagnosis. This study compared 3 common measurement methods: A-B, Ellipse, and Trace to evaluate their reliability and accuracy.
Methods: Two observers (experienced hand surgeon and orthopedic surgery resident) measured median nerve CSA in 10 patients with suspected CTS.
Microsurgical Outcomes in 1000 Patients With Cerebellopontine Angle Tumors: A Comprehensive Cohort Analysis.
Otolaryngol Head Neck Surg
September 2025
Department of Otolaryngology-Head and Neck Surgery, University of California, San Diego, La Jolla, California, USA.
Objective: To summarize the outcomes of 1000 consecutive microsurgical resection of cerebellopontine angle tumors.
Study Design: Retrospective cohort study.
Setting: Single tertiary care institution.
[Outcomes of modified lateral orbital wall decompression using ultrasonic bone removal].
Vestn Oftalmol
September 2025
National Medical Research Center for Endocrinology, Moscow, Russia.
Objective: This study presents a comparative analysis of outcomes of lateral orbital wall decompression performed using ultrasonic bone removal with standard and modified techniques.
Material And Methods: The study included 78 patients (109 orbits) with exophthalmos without visual impairment (subgroups 1A and 1B) and with optic neuropathy (ON) due to thyroid eye disease (TED) (subgroups 2A and 2B). Lateral wall decompression (LWD) was performed using ultrasonic bone removal with a modified (=58, patient subgroups 1A and 2A) or standard (=51, subgroups 1B and 2B) technique.