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http://dx.doi.org/10.1002/hsr2.1144 | DOI Listing |
BMJ Neurol Open
August 2025
Rheumatology, Cleveland Clinic Abu Dhabi, Abu Dhabi, Abu Dhabi, UAE.
Neuromyelitis optica spectrum disorder (NMOSD) is a rare relapsing autoimmune disease of the central nervous system (CNS). Management during pregnancy is challenging due to limited safety data for disease-modifying therapies. We report a case of a 41-year-old woman with aquaporin-4 (AQP4) IgG positive NMOSD who was switched from rituximab to ravulizumab during pregnancy.
View Article and Find Full Text PDFJ Radiol Prot
September 2025
National Cancer Institute Division of Cancer Epidemiology and Genetics, Bethesda, Maryland, UNITED STATES.
Exposure to radioactive iodine (radioiodine) during pregnancy and lactation poses unique risks to both mothers and their offspring due to altered iodine metabolism and heightened radiosensitivity. Existing biokinetic models, such as those developed by Berkovski, have provided a foundation for understanding iodine kinetics in these physiological states but lack integration with the latest International Commission on Radiological Protection (ICRP) reference model for non-pregnant adults. In this study, we developed integrated biokinetic models for pregnancy and lactation that are structurally consistent with the ICRP Publication 137 adult iodine model.
View Article and Find Full Text PDFCureus
July 2025
Research and Education Division, Medical Care and Research, Mérida, MEX.
Autoimmune diseases present a clinical challenge for young women of childbearing age since pregnancy can affect their progression and lead to complications for both mother and baby. Systemic lupus erythematosus (SLE) is of particular interest in this context due to its association with an increased risk of spontaneous abortion, foetal death, pre-eclampsia, intrauterine growth restriction, preterm delivery, and various neonatal manifestations, including thrombocytopenia. In this context, autoimmune neonatal thrombocytopenia, caused by the transplacental transfer of maternal autoantibodies, may be the first sign of an undiagnosed autoimmune disease in the mother.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, United States of America.
Background: Maternal immunization relies on active transplacental transfer of immunoglobulin G. However, very little is known about the efficacy of maternal immunization in the setting of multiple gestation. We aimed to investigate transplacental transfer of maternal antibody in pregnancies with multiple gestation including mono- and dichorionic pregnancies by evaluating anti-Spike antibody transfer at delivery.
View Article and Find Full Text PDFJ Antimicrob Chemother
September 2025
Assistance Publique-Hôpitaux de Paris, Service de Gynécologie-Obstétrique, Hôpital Louis Mourier, Colombes, France.
Objectives: There have been few studies in pregnant women of medications that are used to reduce severe complications from COVID-19 infection. Currently, nirmatrelvir/ritonavir (Paxlovid) is recommended by the National Institutes for Health to treat non-hospitalized pregnant patients with mild-to-moderate COVID-19 illness. The aim of this study was to determine the transplacental passage of molnupiravir, nirmatrelvir/ritonavir and favipiravir utilizing an ex vivo placental perfusion model.
View Article and Find Full Text PDF