Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Introduction: The risk factors for persistent fatigue and cognitive complaints after infection with SARS-CoV-2 and the underlying pathophysiology are largely unknown. Both clinical factors and cognitive-behavioural factors have been suggested to play a role in the perpetuation of complaints. A neurobiological aetiology, such as neuroinflammation, could be the underlying pathophysiological mechanism for persisting complaints.To unravel factors associated with persisting complaints, VeCosCO will compare individuals with and without persistent fatigue and cognitive complaints >3 months after infection with SARS-CoV-2. The study consists of two work packages. The first work package aims to (1) investigate the relation between persisting complaints and neuropsychological functioning; (2) determine risk factors and at-risk phenotypes for the development of persistent fatigue and cognitive complaints, including the presence of postexertional malaise and (3) describe consequences of persistent complaints on quality of life, healthcare consumption and physical functioning. The second work package aims to (1) determine the presence of neuroinflammation with [F]DPA-714 whole-body positron emission tomography (PET) scans in patients with persisting complaints and (2) explore the relationship between (neuro)inflammation and brain structure and functioning measured with MRI.
Methods And Analysis: This is a prospective case-control study in participants with and without persistent fatigue and cognitive complaints, >3 months after laboratory-confirmed SARS-CoV-2 infection. Participants will be mainly included from existing COVID-19 cohorts in the Netherlands covering the full spectrum of COVID-19 acute disease severity. Primary outcomes are neuropsychological functioning, postexertional malaise, neuroinflammation measured using [F]DPA-714 PET, and brain functioning and structure using (f)MRI.
Ethics And Dissemination: Work package 1 (NL79575.018.21) and 2 (NL77033.029.21) were approved by the medical ethical review board of the Amsterdam University Medical Centers (The Netherlands). Informed consent is required prior to participation in the study. Results of this study will be submitted for publication in peer-reviewed journals and shared with the key population.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314688 | PMC |
| http://dx.doi.org/10.1136/bmjopen-2023-072611 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Patient-centred interprofessional teleconsultation for post-viral symptom complexes in German primary care-protocol for the cluster-randomised controlled COVI-Care M-V trial.
BMC Health Serv Res
September 2025
Institute of General Practice, Rostock University Medical Center, Doberaner Str. 142, Rostock, 18057, Germany.
Background: Post-viral syndromes, including long- and post-COVID, often lead to persistent symptoms such as fatigue and dyspnoea, affecting patients' daily lives and ability to work. The COVI-Care M-V trial examines whether interprofessional, patient-centred teleconsultations, initiated by general practitioners in cooperation with specialists, can help reduce symptom burden and improve care for patients.
Methods: To evaluate the effectiveness of the intervention under routine care conditions, a cluster-randomised controlled trial is being conducted.
Association of acute COVID-19 severity and long COVID fatigue and quality of life: Prospective cohort multicenter observational study.
Medicine (Baltimore)
September 2025
Institute for Medical Education, University of Bern, Bern, Switzerland.
Long COVID, or post-COVID-19 condition, is characterized by symptoms persisting beyond 12 weeks after severe acute respiratory syndrome coronavirus 2 infection, affecting individuals regardless of acute disease severity. Fatigue - often linked with depression and anxiety - is among its most debilitating manifestations. However, the associations between fatigue subtypes (physical vs mental), mental health symptoms, and acute disease severity on long-term health-related quality of life (HRQoL) remain unclear.
View Article and Find Full Text PDFAge-related differences in the step-to-step control of foot placement during prolonged walking.
J Biomech
August 2025
Lampe Joint Department of Biomedical Engineering, UNC Chapel Hill & NC State University, Chapel Hill, NC, USA. Electronic address:
Walking is essential for maintaining independence and quality of life, yet aging may impair the neuromuscular function required for stable gait over time. This study sought to quantify age-related differences in step-to-step control during prolonged walking using detrended fluctuation analysis (DFA). We hypothesized that step-to-step changes in step length and step width would exhibit reduced temporal persistence over time, with more pronounced effects in older than in younger adults.
View Article and Find Full Text PDFAssociations Between Inflammatory and Catecholamine Markers and Clinical Outcomes in People with Post-Acute SARS-CoV-2 Infection.
Int J Gen Med
September 2025
Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, USA.
Purpose: The diagnosis of post-acute SARS-CoV-2 infection (PASC) is broad, referring to new or persistent health problems >four weeks after being infected with SARSCoV-2. The aim of this study was to determine whether cytokines, chemokines or catecholamine levels could specify the clinical condition.
Patients And Methods: Seventy-nine participants participated in person to study PASC.
Infective Endocarditis Presenting as Unexplained Iron Deficiency Anaemia: A Diagnostic Challenge.
Cureus
August 2025
Acute Internal Medicine, University Hospitals of North Midland, Royal Stoke University Hospital, Stoke-on-Trent, GBR.
Infective endocarditis is a potentially fatal condition that can present with non-specific symptoms and rare hematologic manifestations, posing significant diagnostic challenges. We report a compelling case of a 67-year-old male with a history of type 2 diabetes, hypertension, and hyperlipidemia who sought medical attention for a five-month history of progressive iron deficiency anemia, accompanied by weight loss, fatigue, and vague constitutional symptoms. Initial extensive workup, including computed tomography of the thorax, abdomen, and pelvis, gastroscopy, colonoscopy, and transthoracic echocardiography, failed to identify an underlying cause.
View Article and Find Full Text PDF