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The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation. | LitMetric
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The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation.

Charles L Limoli , Eniko A Kramár , Aymeric Almeida , Benoit Petit , Veljko Grilj , Janet E Baulch , Paola Ballesteros-Zebadua , Billy W Loo , Marcelo A Wood , Marie-Catherine Vozenin

Radiother Oncol

Laboratory of Radiation Oncology, Department of Radiation Oncology. Lausanne University Hospital and University of Lausanne, Switzerland. Electronic address:

Published: September 2023

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Article Abstract

Long-term potentiation (LTP) was used to gauge the impact of conventional and FLASH dose rates on synaptic transmission. Data collected from the hippocampus and medial prefrontal cortex confirmed significant inhibition of LTP after 10 fractions of 3 Gy (30 Gy total) conventional radiotherapy. Remarkably, 10x3Gy FLASH radiotherapy and unirradiated controls were identical and exhibited normal LTP.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11045040PMC
http://dx.doi.org/10.1016/j.radonc.2023.109767DOI Listing

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