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Rationale And Objectives: Syringeless power injectors obviate the need for reloading iodinated contrast media (ICM) and plastic consumable pistons between exams. This study evaluates the potential time and material waste (ICM, plastic, saline, and total) saved using a multi-use syringeless injector (MUSI) compared to a single-use syringe-based injector (SUSI).
Materials And Methods: Two observers recorded technologist time spent using a SUSI and a MUSI over three clinical workdays. CT technologists (n = 15) were polled on their experience between the systems using a 5-point Likert scale survey. ICM, plastic, and saline waste data from each system were collected. A mathematical model was created to estimate total and categorical waste from each injector system over a 16-week period.
Results: On average, CT technologists spent 40.5 seconds less per exam with MUSI compared to SUSI (p < .001). Technologists rated MUSI work efficiency, user-friendliness, and overall satisfaction (strongly or somewhat improved) higher relative to SUSI (p < .05). Iodine waste was 31.3 L and 0.0 L for SUSI and MUSI, respectively. Plastic waste was 467.7 kg and 71.9 kg for SUSI and MUSI, respectively. Saline waste was 43.3 L and 52.5 L for SUSI and MUSI, respectively. Total waste was 555.0 kg and 124.4 kg for SUSI and MUSI respectively.
Conclusion: Switching from SUSI to MUSI resulted in a 100%, 84.6%, and 77.6% reduction in ICM, plastic, and total waste. This system may fortify institutional endeavors toward green radiology initiatives. The potential time saved administering contrast using MUSI may improve CT technologist efficiency.
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http://dx.doi.org/10.1016/j.acra.2023.05.038 | DOI Listing |
bioRxiv
August 2025
Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago, Chile.
Whole-brain models are valuable tools for understanding brain dynamics in health and disease by enabling the testing of causal mechanisms and identification of therapeutic targets through dynamic simulations. Among these models, biophysically inspired neural mass models have been widely used to simulate electrophysiological recordings, such as MEG and EEG. However, traditional models face limitations, including susceptibility to hyperexcitation, which constrains their ability to capture the full richness of neural dynamics.
View Article and Find Full Text PDFNat Commun
August 2025
Univ Rouen Normandie, INSERM NorDiC UMR 1239, Rouen, France.
Non-small cell lung cancers (NSCLCs) treated with tyrosine kinase inhibitors (TKIs) of the epidermal growth factor receptor (EGFR) almost invariably relapse in the long term, due to the emergence of subpopulations of resistant cells. Through a DNA barcoding approach, we show that the clinically approved drug sorafenib specifically abolishes the selective advantage of EGFR-TKI-resistant cells, while preserving the response of EGFR-TKI-sensitive cells. Sorafenib is active against multiple mechanisms of resistance/tolerance to EGFR-TKIs and its effects depend on early inhibition of MAPK-interacting kinase (MKNK) activity and signal transducer and activator of transcription 3 (STAT3) phosphorylation, and later down-regulation of MCL1 and EGFR.
View Article and Find Full Text PDFMar Pollut Bull
August 2025
National Marine Environmental Monitoring Center, 42, Linghe Street, Dalian 116023, China.
Following a number of meetings devoted to knowledge sharing, identification of key issues, and discussing the best ways to move forward, a wide international expert community is now able to provide recommendations regarding the monitoring of seafloor macrolitter through observation and imaging. As the seafloor constitutes a major sink for marine litter including plastics, it is important to acquire robust and extensive data on litter distribution, abundance, types and size ranges across marine habitats. This should be done through widely agreed, harmonised, and non-destructive methods encompassing advanced technologies.
View Article and Find Full Text PDFmedRxiv
July 2025
Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Objectives: Polygenic hazard score (PHS) models can be used to predict the age-associated risk for complex diseases, including Alzheimer's disease (AD). In this study, we present an improved PHS model for AD that incorporates a large number of genetic variants and demonstrates enhanced predictive accuracy for age of onset in European populations compared to alternative models.
Methods: We used the genotyped European Alzheimer & Dementia Biobank (EADB) sample (n=42,120) to develop and evaluate the performance of the PHS model.
Methods Mol Biol
August 2025
Laboratory of Biomedical Embryology and Tissue Engineering, Department of Veterinary Medicine and Animal Sciences, Centre for Stem Cell Research, Università degli Studi di Milano, Lodi, Italy.
Several early developmental events remain unclear due to ethical and technical limitations related to the use of natural embryos. To overcome this problem, over the last decade, different approaches aimed at the generation of in vitro blastocyst-like models have been developed.Here, we describe a protocol that combines miR-200-mediated cell reprogramming and mechanical stimuli to create 3D spheroids phenotypically similar to natural embryos.
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