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Autoimmune hemolytic anemia can be caused by infections, lymphoproliferative disorders, autoimmune disorders, or triggered by drugs or toxins. We present the case of a 92-year-old man admitted with gastrointestinal symptoms. He presented with autoimmune hemolytic anemia. The etiologic study was negative for autoimmune conditions or solid masses. Viral serologies were negative, and RT-PCR for SARS-CoV-2 was positive. The patient began treatment with corticoid, with resulted in cessation of hemolysis and improvement of the anemia. A few cases of autoimmune hemolytic anemia have been reported in COVID-19 patients. In this case, the infection seems to coincide with the hemolysis period, and we found no other cause for this event. So, we highlight the need to search for SARS-CoV-2 as a possible infective cause of autoimmune hemolytic anemia.
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http://dx.doi.org/10.7759/cureus.39566 | DOI Listing |
ACG Case Rep J
October 2024
Department of Medicine, Division of Gastroenterology and Hepatology, University of Maryland Medical System, Baltimore, MD.
Tofacitinib is a Janus kinase inhibitor commonly used in the management of rheumatoid arthritis and moderate-to-severe ulcerative colitis. Anemia is a rare side effect of this medication often with minimal changes in hemoglobin levels. We report the first case of autoimmune hemolytic anemia from tofacitinib use in a patient with inflammatory bowel disease.
View Article and Find Full Text PDFSemin Arthritis Rheum
August 2025
Grupo IRIDIS (Investigation in Rheumatology and Immune-Diseases), Instituto de Investigación Sanitaria Galicia Sur, (IISGS), Hospital Universitario Vigo, Vigo, Spain.
Introduction: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disorder characterized by multi-organ involvement and variable clinical manifestations. Recurrent clinical patterns suggest distinct phenotypes, where cluster analysis of autoantibodies could identify prognostic subtypes.
Objectives: To define and describe serological clusters and their clinical-epidemiological characteristics, as well as their association with comorbidities, disease activity measures, severity, and damage.
Rinsho Ketsueki
September 2025
Department of Hematology, Kawasaki Medical School.
Warm autoimmune hemolytic anemia (wAIHA) is an autoimmune disorder in which autoantibodies target the patient's own red blood cells. It can be classified as either idiopathic (primary) or secondary and is characterized by the presence of pan-reactive immunoglobulin G (IgG) autoantibodies that recognize epitopes on erythrocyte membrane proteins such as band 3 and Rh polypeptides. Spontaneous remission is rare, and corticosteroids are commonly used as first-line therapy.
View Article and Find Full Text PDFAnn Med Surg (Lond)
September 2025
Department of Biomedical and Laboratory Science, Africa University, Mutare, Zimbabwe.
Thrombotic microangiopathies (TMAs) encompass a diverse group of syndromes marked by microvascular thrombosis, thrombocytopenia, and organ injury, primarily affecting the kidneys and central nervous system. While the etiologies differ-ranging from genetic mutations to infectious and autoimmune triggers-a unifying pathogenic mechanism is endothelial dysfunction. Recent advances have illuminated the pivotal role of cytokine dysregulation in initiating and sustaining this vascular injury.
View Article and Find Full Text PDFAnn Med Surg (Lond)
September 2025
Department of Internal Medicine, Kathmandu University School of Medical Sciences, Dhulikhel, Nepal.
Introduction And Importance: Systemic sclerosis (SSc) is a rare autoimmune disease characterized by fibrosis of internal organs and vasculopathy. It commonly involves the skin and multiple organs, including the kidneys and cardiovascular system. Cardiac tamponade in SSc is an uncommon manifestation, often occurring alongside scleroderma renal crisis (SRC).
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