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The aim of this case report is to describe the treatment of a maxillary right central incisor with pulpal necrosis and incomplete root formation. The 14-year-old patient had experienced trauma to both maxillary central incisors approximately 2 years earlier. Therapy consisted of apexification with a bioceramic reparative cement to form an apical plug. After the clinical and radiographic evaluations, the clinician opened the crown, performed the chemical-mechanical preparation, and placed calcium hydroxide-based medication. At the next appointment, 24 days later, the intracanal medication was removed through passive ultrasonic instrumentation; the canal was dried; and the bioceramic cement was inserted into the apical portion with the aid of a mineral trioxide aggregate holder. A sterile cotton ball, moistened with distilled water, was used to maneuver the material in the apical region, and a periapical radiograph was exposed to confirm the correct placement of the bioceramic reparative cement. The canal was filled with gutta percha cones and a bioceramic root canal sealer. All procedures were performed with the aid of microscopic magnification. Clinical and radiographic evaluations at the 18-month follow-up visit showed that the treated tooth was asymptomatic, suggesting that the bioceramic reparative cement is effective for apexification.
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Adv Healthc Mater
August 2025
Department of Orthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai
Deep carious lesions can progressively demineralize dentin and approach the pulp chamber, risking pulp exposure. Indirect pulp capping seeks to preserve remaining dentin and induce reparative dentin formation to protect the pulp and avoid root canal therapy. However, conventional pulp-capping materials often lack sustained remineralization and sufficient dentinogenic induction.
View Article and Find Full Text PDFbioRxiv
May 2025
Division of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH, USA.
Introduction: Vital pulp treatments (VPT) aim to conservatively manage deep caries and/or damage to preserve the vitality and function of the pulp. This minimally invasive approach is still debated when performing direct pulp capping (DPC), a treatment in which a protective biocompatible material is directly placed over the dental pulp, due to microbial risks inherent with pulp exposure and difficulties in sealing the exposure to protect the pulp from subsequent bacterial ingress. Several limitations associated with Mineral Trioxide Aggregate (MTA) such as long setting time and discoloration have promoted the development of next-generation MTA derivatives with enhanced physical, chemical, and biological properties.
View Article and Find Full Text PDFBMC Oral Health
March 2025
Department of Endodontics, Faculty of Dentistry, Sinai University, Kantara Campus, El Qantara El Sharqiya, Ismailia, Egypt.
Background: Therapeutic quality of endodontic sealers plays a critical role in promoting the success of root canal therapy by blocking entrance of microbes as well as facilitating tissue reparative process. The bioceramic sealers NeoSEALER Flo and CeraSeal have been on the rise owing to their biocompatibility and bioactivity. However, their relations with periapical tissues especially human gingival fibroblasts (HGFs) are still significant determinants of treatment outcomes.
View Article and Find Full Text PDFInt Endod J
May 2025
Department of Endodontics, Fluminense Federal University, Rio de Janeiro, Brazil.
Background: The formation of a reparative hard tissue bridge is a key indicator of defensive pulp response and successful vital pulp treatment (VPT); however, there is a lack of comprehensive information regarding the impact of bioactive materials on hard tissue formation.
Objectives: This systematic review with meta-analyses aimed to evaluate the hard tissue bridge formation in direct pulp capping and pulpotomies in humans, comparing the use of ProRoot MTA with other calcium silicate-based cements (CSCs) and calcium hydroxide.
Methods: The search was conducted in six electronic databases, until May 2024.
Acta Odontol Latinoam
September 2024
Laboratorio de Bioingeniería de Tejidos, División de Estudios de Posgrado e Investigación, Facultad de Odontología, Universidad Nacional Autónoma de México.
Maintaining pulp vitality and function is a priority of the medicaments employed in pulp therapy to preserve tooth integrity. Aim: This study evaluated inflammatory response and reparative dentin bridge formation after direct pulp capping with two different bioceramics. Materials and Method: This was an in vivo controlled experimental study on 12 male Wistar rats.
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