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http://dx.doi.org/10.1681/ASN.0000000000000176 | DOI Listing |
Urology
July 2025
Department of Urology, University of Florida, Gainesville, FL. Electronic address:
Objective: To assess how spot urinary oxalate measurements may uncover post-prandial spikes in oxalate excretion and the impact of hydration on urinary oxalate concentration after a high-oxalate load (HOL).
Methods: Healthy non-stone formers (n = 21) were prospectively enrolled and collected 48 hours of consecutive urine on low oxalate diet. At noon on both days, participants consumed HOL (10 oz.
J Biol Chem
August 2025
Department of Medicine and Surgery, University of Perugia, Perugia, Italy. Electronic address:
Primary hyperoxaluria type 1 (PH1) is caused by the functional deficit of alanine: glyoxylate aminotransferase (AGT1), resulting in a build-up of oxalate. PH1 is diagnosed through the detection of biallelic pathogenic/likely pathogenic variations in the AGXT gene. However, the widespread availability of genetic screening has led to an increased identification of novel variants in patients, yet precisely determining their pathogenicity remains a challenge.
View Article and Find Full Text PDFJ Endourol
August 2025
Department of Urology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Urine oxalate excretion influences the risk of calcium oxalate kidney stone formation and has been reported to positively correlate with body mass index (BMI) and body weight. The two major sources of urine oxalate are dietary oxalate absorption and endogenous oxalate synthesis (EOS). In this study, we investigated the association between EOS, as estimated by oxalate content of 24-hour urine collected while consuming an ultra-low oxalate diet, and measures of body size and composition.
View Article and Find Full Text PDFJ Nephrol
July 2025
Analytical Chemistry and Kidney Stone, Laboratory, AO Ordine Mauriziano, Turin, Italy.
Lumasiran, an RNA interference therapeutic, demonstrated effectiveness in clinical trials, leading to approval for primary hyperoxaluria type 1 management in all age groups. To date, little is known about its use in newborns. This study assesses, for the first time, the oxalate and glycolate metabolism in a newborn affected by primary hyperoxaluria type 1 treated at birth.
View Article and Find Full Text PDFInt Immunopharmacol
August 2025
Department of Pathogenobiology, College of Basic Medical Sciences, Jilin University, Changchun 130021, Jilin Province, China. Electronic address:
Background: Unlike other gluconeogenesis activators, oxaloacetate serves as both a metabolic intermediate and a signaling molecule, offering unique advantages in cancer therapy. This study explores the therapeutic potential of oxaloacetate in hepatocellular carcinoma, focusing on its impact on glucose metabolism, cell apoptosis, and intracellular signaling pathways.
Methods: Utilizing bioinformatics analysis, we evaluated the metabolic flux of glucose in tumors and conducted differential and prognostic analyses of gluconeogenesis genes.