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Article Abstract
A novel radical cascade trifluoromethylthiolation/cyclization of dienes (-alkyl-2-(1-phenylvinyl)aniline derivatives) with AgSCF has been developed. This approach provides simple and efficient access to a wide range of SCF-containing medium-sized rings (7/8/9-membered heterocycles). Preliminary mechanistic studies suggest that the reaction is realized through a silver-assisted radical cascade cyclization process. The large-scale experiment and modification of the product reveal the promising utility of this protocol.
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| http://dx.doi.org/10.1021/acs.orglett.3c01714 | DOI Listing |
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