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Objective: To explore how placental pathology is currently used by clinicians and what placental information would be most useful in the immediate hours after delivery.
Study Design: We used a qualitative study design to conduct in-depth, semi-structured interviews with obstetric and neonatal clinicians who provide delivery or postpartum care at an academic medical center in the US (n = 19). Interviews were transcribed and analyzed using descriptive content analysis.
Results: Clinicians valued placental pathology information yet cited multiple barriers that prevent the consistent use of pathology. Four main themes were identified. First, the placenta is sent to pathology for consistent reasons, however, the pathology report is accessed by clinicians inconsistently due to key barriers: difficult to find in the electronic medical record, understand, and get quickly. Second, clinicians value placental pathology for explanatory capability as well as for contributions to current and future care, particularly when there is fetal growth restriction, stillbirth, or antibiotic use. Third, a rapid placental exam (specifically including placental weight, infection, infarction, and overall assessment) would be helpful in providing clinical care. Fourth, placental pathology reports that connect clinically relevant findings (similar to radiology) and that are written with plain, standardized language and that non-pathologists can more readily understand are preferred.
Conclusion: Placental pathology is important to clinicians that care for mothers and newborns (particularly those that are critically ill) after birth, yet many problems stand in the way of its usefulness. Hospital administrators, perinatal pathologists, and clinicians should work together to improve access to and contents of reports. Support for new methods to provide quick placenta information is warranted.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249791 | PMC |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0286294 | PLOS |
J Pathol
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Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo (ICB/USP), São Paulo, Brazil.
We hypothesized that variants in inflammasome-related genes could influence susceptibility to gestational malaria (GM). To test this, we conducted an association study in a cohort of pregnant women from a malaria-endemic region in northern Brazil, assessing whether specific functional single nucleotide variants (SNVs) in inflammasome genes affect (1) the response to Plasmodium infection and (2) the development of placental malaria. Our findings revealed that the NLRP1 p.
View Article and Find Full Text PDFBlood Vessel Thromb Hemost
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Cardeza Foundation for Hematologic Research, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA.
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View Article and Find Full Text PDFDrug Target Insights
August 2025
Department of Gynecology, Shanghai University of Traditional Chinese Medicine affiliated Shuguang Hospital Anhui Hospital, Anhui, Hefei - China.
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Materials And Methods: The active ingredients of Bushenhuoxue formula (Drug) were acquired from our previous study.
Clin Anat
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Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bibinagar, Telangana, India.
Hyrtl's anastomosis, a transverse inter-arterial connection between the two umbilical arteries near their placental insertion, plays a vital role in maintaining hemodynamic stability in fetal circulation. Despite being a consistent finding in most term placentas, its functional role and clinical significance are underappreciated in perinatal medicine. This review explores the anatomy, physiological function, diagnostic assessment, and clinical implications of Hyrtl's anastomosis, with emphasis on its protective role in ensuring balanced placental perfusion and mitigating hemodynamic stress in compromised pregnancies.
View Article and Find Full Text PDFArch Med Res
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Departamento de Biología de la Reproducción Dr. Carlos Gual Castro Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México City, Mexico. Electronic address:
In the developmental origins of health and disease (DOHaD) paradigm, there is a clear link between an adverse prenatal environment and the development of non-hereditary diseases later in life. Exposure to intrauterine inflammation, for example, has been associated with several late-onset conditions, including neurological, cardiovascular, immune, and metabolic disorders. Moreover, maternal and fetal health are compromised under exacerbated inflammation, as it can result in spontaneous abortion, preterm delivery, or intrauterine growth restriction.
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