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Moebius syndrome (MS) is a rare congenital neuromuscular disorder characterized by weakness or paralysis (palsy) of abducens and facial nerves, or other cranial nerves which may be affected. Diagnosis, treatment, and dental management of MS patients are focused on treating manifestations like malocclusion, while catering to associated extraoral (neurologic, dermatologic, ocular) complications, aiming to improve their quality of life. Here, we report the case of a 9-year-old female patient with MS who underwent orthodontic camouflage using combined orthopedic-orthodontic therapy using a high-pull chin cup and fixed orthodontic appliance to improve skeletal mal-relation and facial appearance. The outcome displayed great improvement in function and better esthetics, improving not only the patient's but also the family's quality of life. A year's follow-up showed successful maintenance of the achieved results. A multidisciplinary approach in MS not only helps in overcoming the treatment challenges but also provides great psychosocial benefits to these patients.
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http://dx.doi.org/10.1111/scd.12888 | DOI Listing |
J Craniofac Surg
August 2025
Department of Plastic Surgery, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands.
Facial palsy in children and adolescents can impair facial expression, emotional communication, and social interaction, potentially leading to reduced quality of life (QoL). However, the extent of available research in this population remains unclear. A scoping review was conducted according to PRISMA-ScR guidelines to evaluate the current literature on QoL in children and adolescents with facial palsy and identify knowledge gaps.
View Article and Find Full Text PDFJ Reconstr Microsurg
September 2025
Division of Plastic and Maxillofacial Surgery, Children's Hospital Los Angeles, Los Angeles, California, United States.
Facial nerve palsy in children leads to significant functional impairment and facial asymmetry. While free gracilis muscle transfer (FGMT) is a cornerstone technique for smile reanimation in both pediatric and adult patients, its evaluation has mainly focused on the single metric of commissure excursion. This study seeks to evaluate the effectiveness of FGMT in restoring dynamic smiles in pediatric patients with facial palsy using image analysis.
View Article and Find Full Text PDFGenet Med Open
May 2025
Metabolic Medicine Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
Purpose: To explore the phenotypic spectrum and genetic etiologies of Moebius Syndrome (MBS), a rare neurological disorder defined by congenital, nonprogressive facial weakness and limitations in ocular abduction.
Methods: We applied strict diagnostic criteria and conducted clinical phenotyping of 149 individuals with MBS. Subsequently, we performed exome and/or genome sequencing on 67 of these individuals and 117 unaffected family members.
Cleft Palate Craniofac J
July 2025
Craniofacial Anomalies and Regeneration Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MB, USA.
Congenital facial weakness (CFW) disorders are a heterogeneous group of rare conditions, that present at birth, with reduced facial movement, and mask-like facies. This study utilized a multimodality approach to examine the craniofacial and intraoral phenotypes among CFW disorders: Moebius syndrome (MBS), Hereditary Congenital Facial Palsy (HCFP), β-tubulin isotype 3 syndrome (CFEOM3A-TUBB3), Carey-Fineman-Ziter syndrome (CFZS), and a group of rarer disorders (Other).Prospective cohort study.
View Article and Find Full Text PDFSpec Care Dentist
June 2025
Department of Dentistry, Central Institute, Clinical Hospital of Medical School of the University of São Paulo, São Paulo, São Paulo, Brazil.
Moebius syndrome is a rare congenital disorder of unknown etiology. It is characterized by non-progressive paralysis of the facial and abducens cranial nerves due to atrophy of their nuclei, often accompanied by malformations in the upper and lower limbs. This report aims to highlight the critical role of hospital dentistry in managing a 6-year-old patient with Moebius syndrome.
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