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http://dx.doi.org/10.1111/resp.14527 | DOI Listing |
Curr Opin Pulm Med
September 2025
Division of Infectious Diseases, Department of Medicine.
Purpose Of Review: Cystic fibrosis (CF) and non-CF bronchiectasis can predispose patients to airway infections that are difficult to treat. The purpose of this review is to discuss recently developed anti-infectives which show promise in treating these infections.
Recent Findings: The microbiology underlying respiratory tract infections in persons with CF (pwCF) and non-CF bronchiectasis is complex.
ERJ Open Res
September 2025
Division of Respiratory Medicine and Gastroenterology, School of Medicine, University of Dundee, Dundee, UK.
Bronchiectasis is a chronic respiratory condition characterised by irreversible dilation of the bronchi, leading to recurrent respiratory infections and chronic inflammation. Bacterial infections have been well-recognised as contributors to disease progression as well as potent inducers of exacerbations for decades. However, recent studies have indicated that viruses are present in up to 50% of exacerbations, raising questions over the role viruses may play in bronchiectasis.
View Article and Find Full Text PDFWorld J Radiol
August 2025
Department of Radiology, Cork University Hospital, Cork T12 DC4A, Ireland.
Background: Primary ciliary dyskinesia (PCD) is a rare condition characterised by dysmotile, immotile, or absent cilia. As a result of the impairment in respiratory mucociliary clearance, patients with PCD typically develop neonatal respiratory distress, nasal congestion, otitis media and recurrent respiratory infections leading to bronchiectasis and structural lung changes. These changes have been shown by chest computed tomography (CT) to develop in infancy and early childhood.
View Article and Find Full Text PDFAnn Med Surg (Lond)
September 2025
College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Introduction: Zeta-chain-associated protein kinase 70 () is a tyrosine kinase that plays a crucial role in T-cell activation via the T-cell receptor/CD3 complex and contributes to B-cell signaling. variants can cause a range of immunodeficiencies with variable clinical presentations, including infections and malignancies.
Case Presentation: A 4-year-old boy presented with chronic cough, dyspnea, recurrent chest infections, and failure to thrive.
Lung India
September 2025
Department of Pulmonary Medicine, Apollo Hospitals, Chennai, Tamil Nadu, India.
Bronchiectasis is a chronic airway disease with recurrent exacerbations and hospitalisations. No inhaled antibiotic has shown consistently beneficial effects in trials. This review analyses the evidence on inhaled antibiotics in non-cystic fibrosis bronchiectasis (NCFB), identifies patient traits for their use, and highlights research gaps.
View Article and Find Full Text PDF