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http://dx.doi.org/10.1016/j.ejim.2023.05.024 | DOI Listing |
Allergy
August 2025
Department of Basic Medical Sciences, Facultad de Medicina, Institute of Applied Molecular Medicine Instituto de Medicina Molecular Aplicada Nemesio Diez (IMMA-ND), Universidad San Pablo-CEU, CEU Universities, Urbanizacion Monteprincipe, Madrid, Spain.
AllergoOncology explores the intersection of allergic diseases and cancer, focusing on shared immune mechanisms. While monocytes and macrophages are extensively studied in cancer, their roles in allergic diseases remain underexplored. To address this gap, we conducted a scoping review to systematically characterize the molecular landscape and related pathways of human monocytes and macrophages in allergy.
View Article and Find Full Text PDFClin Chim Acta
August 2025
Faculty of Medicine, AIMST University, Bedong, Kedah 08100, Malaysia.
Breast cancer is the most prevalent carcinoma in women globally, and the identification of sensitive and specific serum biomarkers is important for its early detection, monitoring, and prognosis. Bcl-2 binding component 3 (BBC3), also known as p53 upregulated modulator of apoptosis (PUMA), is a proapoptotic- BH3-only protein whose dysregulated expression in tumor tissues and circulation implicates it as a potential diagnostic biomarker. However, the analytical performance, preanalytical- requirements, and clinical utility of serum BBC3 quantification have not been rigorously assessed according to clinical chemistry- standards.
View Article and Find Full Text PDFSci Prog
August 2025
RAK College of Medical Sciences, RAK Medical and Health Sciences University, Ras-al-Khaimah, United Arab Emirates.
Breast cancer recurrence remains a major cause of mortality, with up to 30% of early-stage patients relapsing as incurable metastatic disease. Conventional surveillance with imaging and serum markers (CA15-3, CEA) lacks the sensitivity and specificity to detect minimal residual disease. This narrative review examines non-invasive biomarkers such as circulating tumor DNA (ctDNA), circulating tumor cells (CTCs) and exosomes and the technologies enhancing their performance.
View Article and Find Full Text PDFFront Oncol
July 2025
Department of Medical Biology, Ege University Medical School, Izmir, Türkiye.
The discovery of microRNAs (miRNAs) and their pivotal role in gene regulation has opened up new avenues for innovative cancer treatments. Recent years have witnessed extensive research into the intricate mechanisms of miRNAs and their impact on solid tumors. These small non-coding RNA molecules are central to gene regulation and are frequently dysregulated in various cancers, particularly solid tumors.
View Article and Find Full Text PDFEpilepsy Behav
August 2025
Pediatric Neurology Department, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-055 Katowice, Poland. Electronic address:
Objective: Epilepsy is among the most prevalent neurological disorders in children, yet its diagnosis remains largely subjective and reliant on clinician expertise. This highlights the need for objective, minimally invasive biomarkers to support early diagnosis and predict drug resistance. Circulating microRNAs (miRNAs) in whole blood present a promising avenue as potential diagnostic and prognostic biomarkers for pediatric epilepsy.
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