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Discovering the hidden link: hematological disorders caused by copper deficiency.
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Division of Hematology, Department of Internal Medicine, Aichi Medical University School of Medicine, 1-1-Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Copper deficiency can lead to anemia, leukopenia, or thrombocytopenia, often mimicking vitamin B deficiency or myelodysplastic syndrome. We review the crucial role of copper in iron metabolism and hematopoiesis, highlighting how high-dose zinc supplementation, gastrointestinal surgeries, and long-term nutritional support can induce deficiency. The pathophysiology involves compromised ferroxidase activity, which hampers iron utilization, and reduced neutrophil survival due to impairment of cytochrome c oxidase and superoxide dismutase.
View Article and Find Full Text PDFACG Clinical Guideline: Malnutrition and Nutritional Recommendations in Liver Disease.
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Departments of Medicine and Pharmacology & Toxicology, Chief of Research Affairs, Division of Gastroenterology, Hepatology and Nutrition, Associate Vice President for Health Affairs/Research, Associate Vice President for Translational Research, Louisville, Kentucky, USA.
Malnutrition, defined as deficiency, excess, or imbalance of nutrients, is a common complication in patients with liver disease, especially those with cirrhosis. Malnutrition may present as an isolated micronutrient deficiency, such as zinc deficiency, and it commonly presents as frailty and/or sarcopenia in patients with advanced liver disease. Patients with cirrhosis and/or alcohol-associated hepatitis should be assessed for malnutrition because it adversely affects patient outcomes including mortality, as well as waitlist and posttransplant outcomes among liver transplant candidates.
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Department of Pediatrics, Showa University School of Medicine, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan.
Zinc is an essential trace element that is crucial for numerous biological processes, including protein synthesis, antioxidant activity, and bone calcification. Preterm infants are at high risk of zinc deficiency owing to inadequate zinc stores at birth and the rapid decline in zinc concentration in breast milk. This study aimed to evaluate the relationship between zinc concentrations in breast milk and zinc supplementation in preterm infants.
View Article and Find Full Text PDFImproved linear growth after routine zinc supplementation in preterm very low birth weight infants.
Pediatr Res
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Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
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Feeding Approach to Optimizing Nutrition in Infants with Congenital Heart Disease.
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Nutrition Service, University of Utah Hospital, Salt Lake City, UT 84112, USA.
Congenital heart disease (CHD) affects 1% of live births globally. Infants with CHD often experience growth faltering and malnutrition due to increased metabolic demands, malabsorption, and feeding intolerance, further worsened by surgical interventions and frequent hospitalizations. Malnutrition in this population is linked to higher morbidity, extended hospital stays, and poor neurodevelopmental outcomes.
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