Article Synopsis
- In 2022, the European Atherosclerosis Society released a consensus statement highlighting the link between lipoprotein(a) [Lp(a)] levels and an increased risk of atherosclerotic cardiovascular disease (ASCVD) and aortic stenosis.
- A new risk calculator was introduced to help assess an individual's lifetime risk for ASCVD, particularly noting that those with high Lp(a) levels may be at greater risk than previously understood.
- The statement also offers practical guidance for managing cardiovascular risk based on Lp(a) levels and addresses common questions regarding Lp(a) measurement and treatment options in everyday clinical practice.
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Article Abstract
In 2022, the European Atherosclerosis Society (EAS) published a new consensus statement on lipoprotein(a) [Lp(a)], summarizing current knowledge about its causal association with atherosclerotic cardiovascular disease (ASCVD) and aortic stenosis. One of the novelties of this statement is a new risk calculator showing how Lp(a) influences lifetime risk for ASCVD and that global risk may be underestimated substantially in individuals with high or very high Lp(a) concentration. The statement also provides practical advice on how knowledge about Lp(a) concentration can be used to modulate risk factor management, given that specific and highly effective mRNA-targeted Lp(a)-lowering therapies are still in clinical development. This advice counters the attitude: "Why should I measure Lp(a) if I can't lower it?". Subsequent to publication, questions have arisen relating to how the recommendations of this statement impact everyday clinical practice and ASCVD management. This review addresses 30 of the most frequently asked questions about Lp(a) epidemiology, its contribution to cardiovascular risk, Lp(a) measurement, risk factor management and existing therapeutic options.
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| http://dx.doi.org/10.1016/j.atherosclerosis.2023.04.012 | DOI Listing |
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